Transition from homeostatic to reactive matrix remodeling is a fundamental adaptive tissue
response to injury, inflammatory disease, fibrosis, and cancer. Alterations in architecture …

Hyaluronan (HA), a major component of the extracellular matrix (ECM), plays a key role in
regulating inflammation. Inflammation is associated with accumulation and turnover of HA …

Hyaluronan (HA) is a linear nonsulfated glycosaminoglycan of the extracellular matrix that
plays a pivotal role in a variety of biological processes. High‐molecular weight HA exhibits …

Tumors are cellular masses formed through dynamic interactions between tumor cells and a
mixed population of stromal cells. Crosstalk between oncogenic and adjacent stromal cells …

Hyaluronan (HA) is a glycosaminoglycan with a simple structure but diverse and often
opposing functions. The biological activities of this polysaccharide depend on its molecular …

Cell-matrix interactions are fundamental to many developmental, homeostatic, immune and
pathologic processes. Hyaluronan (HA), a critical component of the extracellular matrix …

Hyaluronan (HA) has many functions in the extracellular milieu of normal and diseased
tissues. Disease-associated HA accumulation has been shown to predict a worsened …

An important hallmark of tissue remodeling is the dynamic turnover of extracellular matrix
(ECM). ECM performs a variety of functions in tissue repair including scaffold formation …

Signaling from an actively remodeling extracellular matrix (ECM) has emerged as a critical
factor in regulating both the repair of tissue injuries and the progression of diseases such as …

Hyaluronan (HA) is known to be a prominent component of the extracellular matrix in tumors,
and many solid cancers are characterized by aberrant HA metabolism resulting in increased …