Sustained access to nutrients is a fundamental biological need, especially for proliferating
cells, and controlling nutrient supply is an ancient strategy to regulate cellular responses to …

Cells expressing IDO suppress innate and adaptive immunity to promote tolerance by
catabolizing the amino acid tryptophan (Trp) and other indole compounds. Interferon type I …

Indoleamine 2, 3-dioxygenase (IDO) is the first and rate limiting catabolic enzyme in the
degradation pathway of the essential amino acid tryptophan. By cleaving the aromatic indole …

Regulation of adaptive immune responses is critically important to allow the adaptive
immune system to eradicate infections while causing minimal collateral damage to infected …

Indoleamine 2, 3-dioxygenase (IDO) is a heme enzyme that initiates the oxidative
degradation of the least abundant, essential amino acid, l-tryptophan, along the kynurenine …

Abstract Indoleamine 2, 3-dioxygenase (IDO) catalyzes the initial and rate‑limiting step in the
degradation pathway of the essential amino acid tryptophan and is expressed by …

Indoleamine 2, 3-dioxygenase (IDO) has immunoregulatory roles associated with tryptophan
metabolism. These include counter-regulation (controlling inflammation) and acquired …

Abstract Indoleamine 2, 3-dioxygenase (IDO), a metabolic enzyme that catalyzes tryptophan
conversion into kynurenines, is a crucial regulator of immunity. Altered IDO activity is often …

Control of tryptophan metabolism by indoleamine 2, 3‐dioxygenase (IDO) in dendritic cells
(DC s) is a highly versatile regulator of innate and adaptive immune responses. In acute …

The regulation of the interaction between the immune system and antigens, which may lead
to the induction of immune tolerance, is critical both under physiologic conditions and in …