Objective: To describe a pharmacokinetic model of piperacillin concentrations in plasma and
subcutaneous tissue when administered by bolus dosing and continuous infusion in …

The aim of the present study was to evaluate the benefit of monitoring serum piperacillin
concentrations in critically ill patients. This was an 11-month, prospective, observational …

Sufficient antibiotic dosing in septic patients is essential for reducing mortality. Piperacillin-
tazobactam is often used for empirical treatment, but due to the pharmacokinetic (PK) …

Antibiotic dosing in septic shock patients poses a challenge for clinicians due to the
pharmacokinetic (PK) variability seen in this patient population. Piperacillin-tazobactam is …

The objectives of this study were (i) to compare the plasma concentration–time profiles for
first-dose and steady-state piperacillin administered by intermittent or continuous dosing to …

Background Piperacillin levels after standard dosing have been shown frequently to be
subtherapeutic, especially when renal clearance was augmented. Here, we aimed to …

Objective To explore the effects of renal function estimated by measured creatinine
clearance (Cl CR) on trough serum concentration (C min) of piperacillin given to critically ill …

Piperacillin plasma concentrations are known to vary between critically ill patients. However,
there are no comprehensive data on the variability of antibiotic concentrations within the …

Objective Current guidelines for adjusting antimicrobial therapy regimens commonly are
based on drug concentrations measured in plasma. In septic patients, however, the …

Piperacillin-tazobactam is frequently used for empirical and targeted therapy of infections in
critically ill patients. Considerable pharmacokinetic (PK) variability is observed in critically ill …