Mesenchymal stem cells (MSCs) and osteolineage cells contribute to the hematopoietic
stem cell (HSC) niche in the bone marrow of long bones. However, their developmental …

Skeletal stem and progenitor cell populations are crucial for bone physiology.
Characterization of these cell types remains restricted to heterogenous bulk populations with …

How are skeletal tissues derived from skeletal stem cells? Here, we map bone, cartilage,
and stromal development from a population of highly pure, postnatal skeletal stem cells …

Human skeletal stem cells (SSCs) have been discovered in fetal and adult long bones.
However, the spatiotemporal ontogeny of human embryonic SSCs during early …

Bone stroma contributes to the regulation of osteogenesis and hematopoiesis but also to
fracture healing and disease processes. Mesenchymal stromal cells from bone (BMSCs) …

Mesenchymal stem and progenitor cells (MSPCs) contribute to bone marrow (BM)
homeostasis by generating multiple types of stromal cells. MSPCs can be labeled in the …

Mesenchymal stem cells (MSCs) have great clinical potential for the replacement and
regeneration of diseased or damaged tissue. They are especially important in the production …

With very few exceptions, all adult tissues in mammals are maintained and can be renewed
by stem cells that self-renew and generate the committed progeny required. These functions …

Skeletal stem cells (SSCs) reside in the postnatal bone marrow and give rise to cartilage,
bone, hematopoiesis-supportive stroma and marrow adipocytes in defined in vivo assays …

Stem cell regulation and hierarchical organization of human skeletal progenitors remain
largely unexplored. Here, we report the isolation of a self-renewing and multipotent human …