Impaired tissue oxygen delivery is a major cause of organ damage and failure in critically ill
patients, which can occur even when systemic parameters, including cardiac output and …

Oxygen delivery to cells is the basic prerequisite of life. Within the human body, an
ingenious oxygen delivery system, comprising steps of convection and diffusion from the …

In the vascular system, an extensive network structure provides convective and diffusive
transport of oxygen to tissue. In the microcirculation, parameters describing network …

Microvascular dysfunction contributes to the pathogenesis of chronic conditions such as
diabetes and cardiovascular disease and acute critical illnesses such as trauma …

The microcirculation is a functionally independent entity that encompasses of arterioles,
venules, and capillaries, with diameters ranging from 5 μm to 100 μm. The primary goal of …

This review examines experimental evidence that the microvascular dysfunction that occurs
early in sepsis is the critical first stage in tissue hypoxia and organ failure. A functional …

Coupling microcirculation to systemic hemodynamics : Current Opinion in Critical Care
Coupling microcirculation to systemic hemodynamics : Current Opinion in Critical Care Log in or …

A functional microcirculation is essential for adequate tissue perfusion. In critically ill
patients, microvascular function frequently is altered, which can lead to cellular hypoxia …

Shock is defined as a state in which the circulation is unable to deliver sufficient oxygen to
meet the demands of the tissues, resulting in cellular dysoxia and organ failure. In this …

Severe sepsis is defined by organ failure, often of the kidneys, heart, and brain. It has been
proposed that inadequate delivery of oxygen, or insufficient extraction of oxygen in tissue …