Constitutive nuclear factor κB activity is required for survival of activated B cell–like diffuse large B cell lymphoma cells
RE Davis, KD Brown, U Siebenlist… - The Journal of …, 2001 - rupress.org
Gene expression profiling has revealed that diffuse large B cell lymphoma (DLBCL) consists
of at least two distinct diseases. Patients with one DLBCL subtype, termed activated B cell …
of at least two distinct diseases. Patients with one DLBCL subtype, termed activated B cell …
IκB-ζ controls the constitutive NF-κB target gene network and survival of ABC DLBCL
H Nogai, SS Wenzel, S Hailfinger… - Blood, The Journal …, 2013 - ashpublications.org
Constitutive activation of the nuclear factor-κ B (NF-κB) pathway is a hallmark of the
activated B-cell-like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL). Recurrent …
activated B-cell-like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL). Recurrent …
Small molecule inhibitors of IκB kinase are selectively toxic for subgroups of diffuse large B-cell lymphoma defined by gene expression profiling
LT Lam, RE Davis, J Pierce, M Hepperle, Y Xu… - Clinical cancer …, 2005 - AACR
Constitutive activation of the NF-κB pathway is required for survival of the activated B cell–
like (ABC) subgroup of diffuse large B-cell lymphoma (DLBCL). Here we show that a small …
like (ABC) subgroup of diffuse large B-cell lymphoma (DLBCL). Here we show that a small …
B-cell receptor signaling in diffuse large B-cell lymphoma
The importance of understanding the genetic and biochemical basis of B-cell receptor (BCR)
survival signaling in diffuse large B-cell lymphoma (DLBCL) is underscored by the recent …
survival signaling in diffuse large B-cell lymphoma (DLBCL) is underscored by the recent …
Constitutive BR3 receptor signaling in diffuse, large B-cell lymphomas stabilizes nuclear factor-κB–inducing kinase while activating both canonical and alternative …
LV Pham, L Fu, AT Tamayo… - Blood, The Journal …, 2011 - ashpublications.org
Aberrant nuclear factor κB (NF-κB) signaling has been found to be of particular importance
in diffuse, large B-cell lymphoma (DLBCL) cell survival and proliferation. Although the …
in diffuse, large B-cell lymphoma (DLBCL) cell survival and proliferation. Although the …
Critical role of PI3K signaling for NF-κB–dependent survival in a subset of activated B-cell–like diffuse large B-cell lymphoma cells
B Kloo, D Nagel, M Pfeifer, M Grau… - Proceedings of the …, 2011 - National Acad Sciences
The activated B-cell–like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL)
represents a very aggressive human lymphoma entity. Constitutive NF-κB activation caused …
represents a very aggressive human lymphoma entity. Constitutive NF-κB activation caused …
Compensatory IKKα activation of classical NF-κB signaling during IKKβ inhibition identified by an RNA interference sensitization screen
LT Lam, RE Davis, VN Ngo, G Lenz… - Proceedings of the …, 2008 - National Acad Sciences
A subtype of diffuse large B-cell lymphoma (DLBCL), termed activated B-cell-like (ABC)
DLBCL, depends on constitutive nuclear factor-κB (NF-κB) signaling for survival. Small …
DLBCL, depends on constitutive nuclear factor-κB (NF-κB) signaling for survival. Small …
Protein kinase C–associated kinase is required for NF-κB signaling and survival in diffuse large B-cell lymphoma cells
SW Kim, DW Oleksyn, RM Rossi… - Blood, The Journal …, 2008 - ashpublications.org
Diffuse large B-cell lymphoma (DLBCL) is an aggressive and the most common type of non-
Hodgkin lymphoma. Despite recent advances in treatment, less than 50% of the patients are …
Hodgkin lymphoma. Despite recent advances in treatment, less than 50% of the patients are …
Blockade of oncogenic IκB kinase activity in diffuse large B-cell lymphoma by bromodomain and extraterminal domain protein inhibitors
M Ceribelli, PN Kelly, AL Shaffer… - Proceedings of the …, 2014 - National Acad Sciences
In the activated B-cell–like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL), NF-κB
activity is essential for viability of the malignant cells and is sustained by constitutive activity …
activity is essential for viability of the malignant cells and is sustained by constitutive activity …
The alternative RelB NF-κB subunit is a novel critical player in diffuse large B-cell lymphoma
B Eluard, S Nuan-Aliman, N Faumont… - Blood, The Journal …, 2022 - ashpublications.org
Diffuse large B-cell lymphoma (DLBCL) is the most frequent lymphoid malignancy affecting
adults. The NF-κB transcription factor family is activated by 2 main pathways, the canonical …
adults. The NF-κB transcription factor family is activated by 2 main pathways, the canonical …