Purpose Lung cancer is the leading cause of cancer death worldwide, and the predominant
risk factor for its development is smoking. Thymidylate synthase (TYMS) is a key enzyme in …

Although tobacco smoking is the primary risk factor for lung cancer, low dietary folate intake
and suboptimal DNA repair capacity also contribute to lung cancer risk. Thymidylate …

Genetic polymorphisms of thymidylate synthase (TYMS) gene have been reported to be
associated with development or prognosis of several cancers. However, the association …

Background: Thymidylate synthase (TS) catalyzes the methylation of deoxyuridylate to
deoxythymidylate and is involved in DNA methylation, synthesis and repair. Two common …

Background Several studies have evaluated the association between polymorphisms of
thymidylate synthase (TS) and cancer risk in diverse populations but with conflicting results …

Fruits and certain vegetables have a protective effect on gastric cancer (GC) and folate is
one of the nutrients in fruits and vegetables. We hypothesized that the polymorphisms of …

Background: The current study was aimed to elucidate the association of thymidylate
synthase (TYMS) 5'-UTR 28bp tandem repeat and cytosolic serine …

Thymidylate synthase (TYMS) has three polymorphisms that may modulate thymidylate
synthase (TS) expression levels:(1) 28 base pairs (bp) variable number tandem repeat …

Polymorphisms in the untranslated regions (UTRs) of the thymidylate synthase (TS) gene,
which may modulate TS transcription and expression, have been associated with …

Purpose: Methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthetase (TYMS)
are suggested as risk factors for lung cancer. The purpose of this study was to analyze the …