Melanocyte cell death can lead to various melanocyte-related skin diseases including
vitiligo and leukoderma. Melanocytotoxic chemicals are one of the most well-known causes …

BACKGROUND: Dopamine (DA), a monoamine neurotransmitter, is a well-known
neurotoxin and plays an etiologic role in neurodegenerative disorders such as Parkinson's …

Monobenzyl ether of hydroquinone (MBEH) is a Food and Drug Administration approved
drug used for depigmentation therapy of advanced vitiligo. Here, the working mechanism of …

Vitiligo is an autoimmune depigment disease results from extensive melanocytes
destruction. The destruction of melanocyte is thought to be of multifactorial causation …

Rhododendrol, an inhibitor of melanin synthesis developed for lightening/whitening
cosmetics, was recently reported to induce a depigmentary disorder principally at the sites of …

Chemical leukoderma is a skin depigmentation disorder known to occur in manufactural
workplace through contact with chemicals, such as monobenzyl ether of hydroquinone …

The exposure of human skin to 4-(4-hydroxyphenyl)-2-butanone (raspberry ketone, RK) is
known to cause chemical/occupational leukoderma. RK has a structure closely related to 4 …

Vitiligo is an acquired depigmentary disorder of the skin that results from the selective
destruction of melanocytes, generally during the second decade of life and affecting …

Hyper-activated melanocytes are the major cause of skin hyper-pigmentary disorders, such
as freckles and melasma. Increasing efforts have been made to search for materials with …

Chemical leukoderma is an acquired depigmentation of the skin caused by repeated
exposure to specific agents damaging to epidermal melanocytes. Case reports of chemical …