Stromal cells residing in the tumor microenvironment contribute to the development of
therapy resistance. Here we show that chemotherapy-educated mesenchymal stem cells …

The malignant tumor is the main cause of human deaths worldwide. Current therapies
focusing on the tumor itself have achieved unprecedented benefits. Various pro-tumorigenic …

Cancer stem cells (CSCs) modify and form their microenvironment by recruiting and
activating specific cell types such as mesenchymal stem cells (MSCs). Tumor-infiltrating …

Mesenchymal stem or stromal cells (MSCs) are precursor cells that play important roles in
tumorigenesis. MSCs are recruited to tumors from local and distant sources to form part of …

Abstract Background Mesenchymal stem cells (MSCs) play different roles in modulating
tumor progression, growth, and metastasis. MSCs are recruited to the tumor site in large …

Resistance to anticancer therapeutics greatly affects the phenotypic and functional
properties of tumor cells, but how chemoresistance contributes to the tumorigenic activities …

Cancer stem cells (CSCs) have emerged as key contributors to tumor initiation, growth, and
metastasis. In addition, CSCs play a significant role in inducing immune evasion, thereby …

Increasing evidence indicates that the tumor microenvironment appears to play an
increasingly important role in cancer progression and therapeutic resistance. Several types …

The connection between epithelial-mesenchymal (EM) plasticity and cancer stem cell (CSC)
properties has been paradigm-shifting, linking tumor cell invasion and metastasis with …

Mesenchymal stem cells (MSCs) have both stemness and multi-modulatory activities on
other cells, and the immunosuppressive and tumor-promotive mechanisms have been …