Atherosclerosis, characterized by the formation of fat-laden plaques, is a chronic
inflammatory disease. ABCA1 promotes cholesterol efflux, reduces cellular cholesterol …

ATP binding cassette transporter A1 (ABCA1) mediates the cellular efflux of phospholipids
and cholesterol to lipid-poor apolipoprotein A1 (apoA1) and plays a significant role in high …

ABCA1 exports excess cholesterol from cells to apoA-I and is essential for HDL synthesis.
Genetic studies have shown that ABCA1 protects against cardiovascular disease. We have …

Objective—The ATP-binding cassette transporter, subfamily A, member 1 (ABCA1) plays a
key role in HDL cholesterol metabolism. However, the role of ABCA1 in modulating …

ATP-binding cassette transporter A1 (ABCA1) is an integral cell membrane protein that
protects cardiovascular disease by at least two mechanisms: by export of excess cholesterol …

Cholesterol homeostasis plays a significant role in cardiovascular disease. Previous studies
have indicated that ATP-binding cassette transporter A1 (ABCA1) is one of the most …

Background and aims ApoA-1 binding protein (AIBP) is a secreted protein that interacts with
apoA-I and accelerates cholesterol efflux from cells. We have recently reported that AIBP …

Cholesterol-loaded macrophage foam cells are a central component of atherosclerotic
lesions. ABCA1, the defective molecule in Tangier disease, mediates the efflux of …

Rationale Previous studies have shown that apolipoprotein-1 (apoA-1) binding protein
(AIBP) is highly associated with the regulation of apoA-1 metabolism, suggesting its role in …

Background—Macrophage acyl-coenzyme A: cholesterol acyltransferase 1 (ACAT1) and
apolipoprotein E (apoE) have been implicated in regulating cellular cholesterol homeostasis …