Background The four major pathways in gastroenteropancreatic neuroendocrine neoplasms
(GEP-NENs) including chromatin remodeling, DNA damage repair, activation of mTOR …

Neuroendocrine tumors (NETs) are rare cancers that most often arise in the gastrointestinal
tract and pancreas. The fundamental mechanisms driving gastroenteropancreatic (GEP) …

The tumor immune microenvironment (TME) represents a key determinant for responses to
cancer treatment. However, the immune phenotype of highly proliferative …

Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are a group of rare tumors
that are increasing in prevalence. The complex tumor immune microenvironment (TIME) …

Introduction: Most patients with pancreatic neuroendocrine tumors (pNETs) present with
unresectable or metastatic disease. Increasing evidence shows that the immune cell …

Objective Immune infiltration plays an important role in tumor development and progression
and shows promising prognostic value in numerous tumors. In this study, we aimed to …

Gastroenteropancreatic high-grade (HG) neuroendocrine carcinoma (GEP-NEC) is an
aggressive malignancy with limited treatment options and increasing incidence in the United …

High-grade Gastroenteropancreatic Neuroendocrine neoplasms (H-NENs) comprehend
well-differentiated tumors (NET G3) and poorly differentiated carcinomas (NEC) with …

We successfully determined the difference of immune microenvironments between pNENs
and pancreatic ductal adenocarcinomas (PDACs), and the histology-dependent variability …

Microenvironment‐related immune and inflammatory markers, when combined with
established Ki‐67 and morphology parameters, can improve prognostic prediction in gastro …