Viral infection is usually studied at the population level by averaging over millions of cells.
However, infection at the single-cell level is highly heterogeneous, with most infected cells …

Prediction, prevention and treatment of virus infections require understanding of cell-to-cell
variability that leads to heterogenous disease outcomes, but the source of this heterogeneity …

Herpesvirus infection initiates a range of perturbations in the host cell, which remain poorly
understood at the level of individual cells. Here, we quantify the transcriptome of single …

Herpes simplex virus type-1 (HSV-1) is an alpha herpesvirus that infects over 60% of the
human population [1]. Infection results in a variety of disease manifestations, including cold …

ABSTRACT Herpes simplex virus 1 (HSV-1) can undergo a productive infection in
nonneuronal and neuronal cells such that the genes of the virus are transcribed in an …

Lytic infection by herpes simplex virus 1 (HSV-1) triggers a change in many host cell
programs as the virus strives to express its own genes and replicate. Part of this process is …

To date, characterization of latently infected tissue with respect to the number of cells in the
tissue harboring the viral genome and the number of viral genomes contained within …

Herpesviruses utilize multiple mechanisms to redirect host proteins for use in viral processes
and to avoid recognition and repression by the host. To investigate dynamic interactions …

Like other alpha-herpesviruses, Herpes Simplex Virus Type 1 (HSV-1) possesses the ability
to establish latency in sensory ganglia as a non-integrated, nucleosome-associated …

Communication between infected cells and cells in the surrounding tissue is a determinant
of viral spread. However, it remains unclear how cells in close or distant proximity to an …