Background Pyroptosis and oxidative stress play pivotal roles in cardiomyocyte loss after
myocardial infarction. NF-κB is associated with oxidative stress and gasdermin D (GSDMD) …

Diabetic cardiomyopathy (DCM), a serious diabetic complication, is a kind of low-grade
inflammatory cardiovascular disorder. Due to the high risk of morbidity and mortality, DCM …

Dilated cardiomyopathy (DCM) is one of the most common causes of heart failure, and the
underlying mechanism remains largely elusive. Here we investigated whether NLRP3 …

Rationale: Pyroptosis is a morphologically and mechanistically distinct form of cell death and
is characterized by GSDMD (gasdermin D) or GSDME (gasdermin E)-mediated necrosis …

Cinnamaldehyde (CD) is one of the most important active compounds derived from
Cinnamomum cassia and showed multiple biological activities. Accumulating evidence has …

The reactive oxygen species-(ROS-) induced nod-like receptor protein-3 (NLRP3)
inflammasome triggers sterile inflammatory responses and pyroptosis, which is a …

Pyroptosis is a form of pro-inflammatory, necrotic cell death mediated by proteins of the
gasdermin family. Various heart diseases, including myocardial ischemia/reperfusion injury …

Pyroptosis is an inflammatory cell death that regulates cardiomyocyte loss after myocardial
infarction. Reports indicate that nicorandil has a strong anti-inflammatory effect and protects …

Pyroptosis is a form of programmed necrosis, and is morphologically and mechanistically
unique form of programmed cell death compared to others, such as apoptosis and …

Background The NOD–like receptor pyrin domain–containing protein 3 (NLRP3)
inflammasome activation–mediated pyroptosis pathway has been linked to myocardial …