It is evident that the admission of some patients with sepsis and septic shock to hospitals is
occurring late in their illness, which has contributed to the increase in poor outcomes and …

Over the past two decades, elucidation of the host response to severe infection has
uncovered the complex and dynamic derangements in immune, endothelial, and metabolic …

Background Sepsis from infection is a global health priority and clinical trials have failed to
deliver effective therapeutic interventions. To address complicating heterogeneity in sepsis …

Background Novel biomarkers are needed to progress toward individualized patient care in
sepsis. The immune profiling panel (IPP) prototype has been designed as a fully-automated …

Sepsis is a major health issue and a leading cause of death in hospitals globally. The
treatment of sepsis is largely supportive, and there are no therapeutics available that target …

Background Sepsis is defined as a life-threatening condition, resulting from a dysregulated
and harmful response of the hosts' immune system to infection. Apart from this, the (over-) …

Immune therapy to ease the burden of sepsis has thus far failed to consistently improve
patient outcomes. Advances in cancer immune therapy and awareness that prolonged …

Objectives: Sepsis and trauma are common health problems and provide great challenges
in critical care. Diverse patient responses to these conditions further complicate patient …

Sepsis, a critical condition marked by systemic inflammation, profoundly impacts both innate
and adaptive immunity, often resulting in lymphopenia. This immune alteration can spare …

Sepsis is characterised by a dysregulated host immune response to infection. Despite
recognition of its significance, immune status monitoring is not implemented in clinical …