Inflammatory bowel disease (IBD) is characterized by chronic and relapsing intestinal
inflammation, which currently lacks safe and effective medicine. Some previous studies …

Background Restoring immune homeostasis by targeting the Th17/Treg response is a
potentially valuable therapeutic strategy for ulcerative colitis (UC). Astragaloside IV (AS-Ⅳ) …

Disturbed activation of autophagy is implicated in the pathogenesis of inflammatory bowel
disease. Accordingly, several autophagy-related genes have been identified as Crohn's …

Intestinal barrier dysfunction is a trigger for sepsis progression. NLRP3 inflammasome and
RhoA contribute to sepsis and intestinal inflammation. The current study aimed to explore …

Loganin, a major bioactive iridoid glycoside derived from Cornus officinalis, exerts different
beneficial biological properties. Recently, loganin has been reported to exhibit potential anti …

Aberrant M1/M2 macrophage polarization and dysbiosis are involved in the pathogenesis of
ulcerative colitis (UC). Ginsenoside Rg1 exhibits optimal immunomodulatory and anti …

Flos Abelmoschus manihot is widely used as traditional drug in China. Abelmoschus
manihot (AM) extracted from Flos Abelmoschus manihot that has been applied for treating …

Background Colitis-associated colorectal cancer (CAC) is a severe complication of
inflammatory bowel disease (IBD), resulting from long-term inflammation in the intestines …

With the ulcerative colitis (UC) incidence increasing worldwide, it is of great importance to
prevent and treat UC. However, efficient treatment options for UC are relatively limited. Due …

It is common knowledge that the crosstalk of gut microbiota (GM) and dendritic cells (DCs)
are critical for the pathogenesis of inflammatory bowel disease (IBD). As a major bioactive …