The role of the insulin-like growth factor (IGF) system has attracted close attention. The
activity of IGF binding proteins (IGFBPs) within the ovary has not been fully elucidated to …

Objective: To review the available information regarding the roles of insulin‐like growth
factor (IGF)‐IGF binding protein (IGFBP) system in ovarian physiology. Design: Studies that …

Cyclic ovarian follicular development is a complex process that involves proliferation,
differentiation, and death of follicle cells. Gonadotropins produced by the pituitary gland …

The number of growth factors involved in female fertility has been extensively studied, but
reluctance to add essential growth factors in culture media has limited progress in optimizing …

Over the past 20 years, the expression, signaling mechanisms, and roles of members of the
insulin-like growth factor (IGF) family (ligands, receptors, binding proteins, and binding …

The insulin-like growth factors (IGF-I and-II) are ubiquitously expressed factors that regulate
cell growth, differentiation and maintenance of differentiated cell function. All aspects of male …

In the ovary, insulin-like growth factors (IGFs) enhance both proliferation and differentiation
of follicular cells by potentiating gonadotropin's actions. The biological effects of IGFs are …

As the significance of putative intraovarian regulators becomes increasingly recognized,
much of the attention centers on insulin-like growth factors (IGFs). Indeed, a large body of …

The aim of the present article is to update our understanding of the expression of the insulin-
like growth factor binding proteins (IGFBPs), IGFBP proteases and their implication in the …

EXPERIMENTAL evidence has shown that insulinlike growth factors (IGFs) exert a variety of
effects at the level of murine, rabbit, porcine, and human ovarian cells, thereby raising the …