Muscle fibrosis represents the end stage consequence of different diseases, among which
muscular dystrophies, leading to severe impairment of muscle functions. Muscle fibrosis …

Fibrosis, defined as an excessive accumulation of extracellular matrix, is the end point of a
defective regenerative process, unresolved inflammation and/or chronic damage. Numerous …

Skeletal muscle is a highly regenerative tissue that produces contractile forces required for
respiration and locomotion and aids regulation of whole-body energy homeostasis via …

Skeletal muscle is the largest organ of human body with several important roles in everyday
movement and metabolic homeostasis. The limited ability of small animal models of muscle …

Skeletal muscle is a fundamental tissue of the human body with great plasticity and
adaptation to diseases and injuries. Recreating this tissue in vitro helps not only to deepen …

Healthy skeletal muscle possesses the extraordinary ability to regenerate in response to
small‐scale injuries; however, this self‐repair capacity becomes overwhelmed with aging …

Skeletal muscle repair after injury includes a complex and well-coordinated regenerative
response. However, fibrosis often manifests, leading to aberrant regeneration and …

Classical approaches to engineer skeletal muscle tissue based on current regenerative and
surgical procedures still do not meet the desired outcome for patient applications. Besides …

During fibrotic diseases, functional tissue parenchyma progressively transforms into stiff,
disorganized and non-functional tissue causing organ failure. The underlying multitude of …

Introduction With the advances in skeletal muscle tissue engineering, new platforms have
arisen with important applications in biology studies, disease modeling, and drug testing …