Importance Previous evidence has implicated corticostriatal abnormalities in the
pathophysiology of psychosis. Although the striatum is the primary target of all efficacious …

Objective: Clinical response to antipsychotic drug treatment is highly variable, yet prognostic
biomarkers are lacking. The authors recently demonstrated that successful antipsychotic …

Medication management in schizophrenia is a lengthy process, as the lack of clinical
response can only be confirmed after at least 4 weeks of antipsychotic treatment at a …

Background The striatum is abnormal in schizophrenia and possibly represents a common
neurobiological mechanism underlying psychotic disorders. Resting-state functional …

Importance Dysregulation of corticostriatal circuitry has long been thought to be critical in the
etiology of psychotic disorders, although the differential roles played by dorsal and ventral …

Importance Recent data suggest that treatment with antipsychotics is associated with
reductions in cortical gray matter in patients with schizophrenia. These findings have led to …

Published reports of functional abnormalities in schizophrenia remain divergent due to lack
of staging point-of-view and whole-brain analysis. To identify key functional-connectivity …

Objective To describe abnormalities in large scale functional networks in unmedicated
patients with schizophrenia and to examine effects of risperidone on networks. Material and …

To better characterize hippocampal pathophysiology in schizophrenia, we conducted a
longitudinal study evaluating hippocampal functional connectivity during resting state, using …

Schizophrenia has been linked to disturbed connectivity between large-scale brain
networks. Altered thalamocortical connectivity might be a major mechanism mediating …