Radiation‐induced normal tissue damage: oxidative stress and epigenetic mechanisms
J Wei, B Wang, H Wang, L Meng… - Oxidative medicine …, 2019 - Wiley Online Library
Radiotherapy (RT) is currently one of the leading treatments for various cancers; however, it
may cause damage to healthy tissue, with both short‐term and long‐term side effects …
may cause damage to healthy tissue, with both short‐term and long‐term side effects …
Reduction–oxidation (redox) system in radiation-induced normal tissue injury: molecular mechanisms and implications in radiation therapeutics
R Yahyapour, E Motevaseli, A Rezaeyan… - Clinical and …, 2018 - Springer
Every year, millions of cancer patients undergo radiation therapy for treating and destroying
abnormal cell growths within normal cell environmental conditions. Thus, ionizing radiation …
abnormal cell growths within normal cell environmental conditions. Thus, ionizing radiation …
Targeting of cellular redox metabolism for mitigation of radiation injury
Accidental exposure to ionizing radiation is a serious concern to human life. Studies on the
mitigation of side effects following exposure to accidental radiation events are ongoing …
mitigation of side effects following exposure to accidental radiation events are ongoing …
Oxidative damage pathways in relation to normal tissue injury
W Zhao, DI Diz, ME Robbins - The British journal of radiology, 2007 - academic.oup.com
Given the increasing population of long-term cancer survivors, the need to mitigate or treat
late effects has emerged as a primary area of radiation biology research. Once thought to be …
late effects has emerged as a primary area of radiation biology research. Once thought to be …
Molecular pathways associated with oxidative stress and their potential applications in radiotherapy
Radiotherapy is an essential and effective treatment modality for cancer. Excessive levels of
reactive oxygen species (ROS) induced by ionizing radiation disrupt the redox homeostasis …
reactive oxygen species (ROS) induced by ionizing radiation disrupt the redox homeostasis …
Inflammation and chronic oxidative stress in radiation-induced late normal tissue injury: therapeutic implications
W Zhao, MEC Robbins - Current medicinal chemistry, 2009 - ingentaconnect.com
The threat of radiation-induced late normal tissue injury limits the dose of radiation that can
be delivered safely to cancer patients presenting with solid tumors. Tissue dysfunction and …
be delivered safely to cancer patients presenting with solid tumors. Tissue dysfunction and …
Low-dose ionizing radiation exposure, oxidative stress and epigenetic programing of health and disease
S Tharmalingam, S Sreetharan… - Radiation …, 2017 - meridian.allenpress.com
Ionizing radiation exposure from medical diagnostic imaging has greatly increased over the
last few decades. Approximately 80% of patients who undergo medical imaging are …
last few decades. Approximately 80% of patients who undergo medical imaging are …
Targets for protection and mitigation of radiation injury
E Khodamoradi, M Hoseini-Ghahfarokhi… - Cellular and Molecular …, 2020 - Springer
Protection of normal tissues against toxic effects of ionizing radiation is a critical issue in
clinical and environmental radiobiology. Investigations in recent decades have suggested …
clinical and environmental radiobiology. Investigations in recent decades have suggested …
Redox-modulated phenomena and radiation therapy: the central role of superoxide dismutases
AK Holley, L Miao, DK St. Clair… - Antioxidants & redox …, 2014 - liebertpub.com
Significance: Ionizing radiation is a vital component in the oncologist's arsenal for the
treatment of cancer. Approximately 50% of all cancer patients will receive some form of …
treatment of cancer. Approximately 50% of all cancer patients will receive some form of …
Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: a unifying concept in stress response biology
Exposure of eukaryotic cells to ionizing radiation (IR) results in the immediate formation of
free radicals that last a matter of milliseconds. It has been assumed that the subsequent …
free radicals that last a matter of milliseconds. It has been assumed that the subsequent …
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