Radiation‐induced normal tissue damage: oxidative stress and epigenetic mechanisms

J Wei, B Wang, H Wang, L Meng… - Oxidative medicine …, 2019 - Wiley Online Library
Radiotherapy (RT) is currently one of the leading treatments for various cancers; however, it
may cause damage to healthy tissue, with both short‐term and long‐term side effects …

Reduction–oxidation (redox) system in radiation-induced normal tissue injury: molecular mechanisms and implications in radiation therapeutics

R Yahyapour, E Motevaseli, A Rezaeyan… - Clinical and …, 2018 - Springer
Every year, millions of cancer patients undergo radiation therapy for treating and destroying
abnormal cell growths within normal cell environmental conditions. Thus, ionizing radiation …

Targeting of cellular redox metabolism for mitigation of radiation injury

B Farhood, M Ashrafizadeh, M Hoseini-Ghahfarokhi… - Life sciences, 2020 - Elsevier
Accidental exposure to ionizing radiation is a serious concern to human life. Studies on the
mitigation of side effects following exposure to accidental radiation events are ongoing …

Oxidative damage pathways in relation to normal tissue injury

W Zhao, DI Diz, ME Robbins - The British journal of radiology, 2007 - academic.oup.com
Given the increasing population of long-term cancer survivors, the need to mitigate or treat
late effects has emerged as a primary area of radiation biology research. Once thought to be …

Molecular pathways associated with oxidative stress and their potential applications in radiotherapy

R Liu, Y Bian, L Liu, L Liu, X Liu… - … Journal of Molecular …, 2022 - spandidos-publications.com
Radiotherapy is an essential and effective treatment modality for cancer. Excessive levels of
reactive oxygen species (ROS) induced by ionizing radiation disrupt the redox homeostasis …

Inflammation and chronic oxidative stress in radiation-induced late normal tissue injury: therapeutic implications

W Zhao, MEC Robbins - Current medicinal chemistry, 2009 - ingentaconnect.com
The threat of radiation-induced late normal tissue injury limits the dose of radiation that can
be delivered safely to cancer patients presenting with solid tumors. Tissue dysfunction and …

Low-dose ionizing radiation exposure, oxidative stress and epigenetic programing of health and disease

S Tharmalingam, S Sreetharan… - Radiation …, 2017 - meridian.allenpress.com
Ionizing radiation exposure from medical diagnostic imaging has greatly increased over the
last few decades. Approximately 80% of patients who undergo medical imaging are …

Targets for protection and mitigation of radiation injury

E Khodamoradi, M Hoseini-Ghahfarokhi… - Cellular and Molecular …, 2020 - Springer
Protection of normal tissues against toxic effects of ionizing radiation is a critical issue in
clinical and environmental radiobiology. Investigations in recent decades have suggested …

Redox-modulated phenomena and radiation therapy: the central role of superoxide dismutases

AK Holley, L Miao, DK St. Clair… - Antioxidants & redox …, 2014 - liebertpub.com
Significance: Ionizing radiation is a vital component in the oncologist's arsenal for the
treatment of cancer. Approximately 50% of all cancer patients will receive some form of …

Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: a unifying concept in stress response biology

DR Spitz, EI Azzam, J Jian Li, D Gius - Cancer and Metastasis Reviews, 2004 - Springer
Exposure of eukaryotic cells to ionizing radiation (IR) results in the immediate formation of
free radicals that last a matter of milliseconds. It has been assumed that the subsequent …