Since the discovery of interleukin-10 (IL-10) in the 1980s, a large body of work has led to its
recognition as a pleiotropic immunomodulatory cytokine that affects both the innate and …

Abstract Interleukin (IL)-10 is an essential anti-inflammatory cytokine and functions as a
negative regulator of immune responses to microbial antigens. IL-10 is particularly important …

Abstract Interleukin (IL)-10 is considered a prototypical anti-inflammatory cytokine, which
significantly contributes to the maintenance and reestablishment of immune homeostasis …

Interleukin-10 (IL-10) is a pleiotropic cytokine that modulates the function of several adaptive
immunity-related cells. Although generally considered an immunosuppressive molecule, IL …

Abstract Interleukin (IL)-10 is an essential anti-inflammatory cytokine that plays important
roles as a negative regulator of immune responses to microbial antigens. Loss of IL-10 …

Abstract Interleukin-10 (IL-10) is known to be a tolerogenic cytokine since it inhibits pro-
inflammatory cytokine production and T cell stimulatory capacities of myeloid cells, such as …

The discovery of IL-10 more than 30 years ago marked the beginning of our understanding
of how cytokines regulate immune responses, based on cross-regulation between Th1 and …

Abstract Interleukin-10 (IL-10), a cytokine with anti-inflammatory properties, has a central
role in infection by limiting the immune response to pathogens and thereby preventing …

The identification of helper T (TH)-cell subsets has greatly improved understanding of the
regulation of immune effector functions. In addition to controlling humoral and delayed-type …

Interleukin (IL)-10 is a cytokine that modulates both innate and adaptive immunity, primarily
by exerting antiinflammatory effects. IL-10 was originally thought to be produced only by T …