Tissue hypoxia contributes to solid tumor pathogenesis by activating a series of adaptive
programs. We previously showed that hypoxia promotes the preferential expansion and …

Hypoxia contributes to the progression of a variety of cancers by activating adaptive
transcriptional programs that promote cell survival, motility and tumor angiogenesis …

Hypoxia promotes the expansion of non-neoplastic stem and precursor cell populations in
the normal brain, and is common in malignant brain tumors. We examined the effects of …

Malignant gliomas are lethal cancers that display cellular hierarchies with cancer stem cells
at the apex. Glioma stem cells (GSCs) are not uniformly distributed, but rather located in …

Glioblastomas are highly lethal cancers that contain cellular hierarchies with self-renewing
cancer stem cells that can propagate tumors in secondary transplant assays. The potential …

Glioblastomas are lethal cancers characterized by florid angiogenesis promoted in part by
glioma stem cells (GSCs). Because hypoxia regulates angiogenesis, we examined hypoxic …

Tissue hypoxia and necrosis represent pathophysiologic and histologic hallmarks of
glioblastoma (GBM). Although hypoxia inducible factor 1α (HIF-1α) plays crucial roles in the …

Tumor hypoxic microenvironment causes hypoxia inducible factor 1 alpha (HIF-1α)
activation and necrosis with alarmins release. Importantly, HIF-1α also controls the …

Hypoxia promotes tumor progression through multiple mechanisms including modifying
angiogenesis, metabolism switch and invasion. Hypoxia inducible factors (HIFs), particularly …

The poor prognosis of glioblastoma multiforme (GBM) is primarily due to highly invasive
glioma stem-like cells (GSCs) in tumors. Upon GBM recurrence, GSCs with highly invasive …