Current disease models of autoimmune syndromes, such as rheumatoid arthritis, propose
that chronic inflammation is caused by 'forbidden T-cell clones' that recognize disease …

Aging is accompanied by a progressive decline in the integrity of the immune system, a
process known as immunosenescence. Pathological features typical of immune dysfunction …

Rheumatoid arthritis (RA), like many other autoimmune syndromes, is a disease of adults,
with the highest incidence rates reported in the elderly. The immune system undergoes …

Immune aging is a complex process rendering the host susceptible to cancer, infection, and
insufficient tissue repair. Many autoimmune diseases preferentially occur during the second …

It is widely accepted that cell-mediated immune functions decline with age, rendering an
individual more susceptible to infection and possibly cancer, as well as to age-associated …

Patients with T‐cell‐mediated autoimmune diseases show immune system abnormalities
that resemble the typical characteristics of autoimmune dysfunction described in the elderly …

The term “immunosenescence” refers to an age-associated dysregulation of immune
function which contributes to the increased susceptibility of the elderly to infectious disease …

Acquired immune function shows recognizable changes over time with organismal aging.
These changes include T-cell dysfunction, which may underlie diminished resistance to …

Beginning with the sixth decade of life, the human immune system undergoes dramatic
aging-related changes, which continuously progress to a state of immunosenescence. The …

The immune system exhibits profound age-related changes, collectively termed
immunosenescence. The most visible of these is the decline in protective immunity, which …