Chronic kidney disease is a leading cause of death in the United States. Tubulointerstitial
fibrosis (TIF) is considered the final common pathway leading to end-stage renal disease …

Kidney fibrosis is a common feature of chronic kidney disease (CKD). A recent study
suggests that abnormal Notch signaling activation contributes to the development of renal …

Kidney fibrosis is the histologic manifestation of CKD. Sustained activation of developmental
pathways, such as Notch, in tubule epithelial cells has been shown to have a key role in …

Notch signalling is a highly conserved cell–cell communication mechanism that regulates
development, tissue homeostasis, and repair. Within the kidney, Notch has an important …

Kidney diseases impart a vast burden on affected individuals and the overall health care
system. Progressive loss of renal parenchymal cells and functional decline following injury …

Kidney fibrosis is a common histological manifestation of functional decline in the kidney.
Fibrosis is a reactive process that develops in response to excessive epithelial injury and …

Recent studies indicate that the Notch signaling pathway plays an important role in the
development of diabetic kidney disease and focal segmental glomerulosclerosis (FSGS) …

Kidney development involves formation of nephrons intricately aligned with the vasculature
and connected to a branched network of collecting ducts. Notch signaling plays multiple …

Notch signaling in kidney development : Current Opinion in Nephrology and Hypertension
Notch signaling in kidney development : Current Opinion in Nephrology and Hypertension Log …

The story of Notch and chronic kidney disease : Current Opinion in Nephrology and
Hypertension The story of Notch and chronic kidney disease : Current Opinion in Nephrology …