[HTML][HTML] Structure of pulmonary surfactant membranes and films: the role of proteins and lipid–protein interactions

J Pérez-Gil - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2008 - Elsevier
The pulmonary surfactant system constitutes an excellent example of how dynamic
membrane polymorphism governs some biological functions through specific lipid–lipid …

[HTML][HTML] Structural hallmarks of lung surfactant: Lipid-protein interactions, membrane structure and future challenges

JC Castillo-Sánchez, A Cruz, J Pérez-Gil - Archives of biochemistry and …, 2021 - Elsevier
Lung surfactant (LS) is an outstanding example of how a highly regulated and dynamic
membrane-based system has evolved to sustain a wealth of structural reorganizations in …

[HTML][HTML] Structure-function relationships in pulmonary surfactant membranes: from biophysics to therapy

E Lopez-Rodriguez, J Pérez-Gil - Biochimica et Biophysica Acta (BBA) …, 2014 - Elsevier
Pulmonary surfactant is an essential lipid–protein complex to maintain an operative
respiratory surface at the mammalian lungs. It reduces surface tension at the alveolar air …

Composition, structure and mechanical properties define performance of pulmonary surfactant membranes and films

E Parra, J Pérez-Gil - Chemistry and physics of lipids, 2015 - Elsevier
The respiratory surface in the mammalian lung is stabilized by pulmonary surfactant, a
membrane-based system composed of multiple lipids and specific proteins, the primary …

Cholesterol rules: direct observation of the coexistence of two fluid phases in native pulmonary surfactant membranes at physiological temperatures

JB de la Serna, J Perez-Gil, AC Simonsen… - Journal of Biological …, 2004 - ASBMB
Pulmonary surfactant, the lipid-protein material that stabilizes the respiratory surface of the
lungs, contains approximately equimolar amounts of saturated and unsaturated …

[HTML][HTML] Pulmonary surfactant: functions and molecular composition

J Goerke - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 1998 - Elsevier
This review briefly notes recent findings important for understanding the surface mechanical
functions of pulmonary surfactant. Currently known surfactant-specific proteins and lipids are …

Protein–lipid interactions and surface activity in the pulmonary surfactant system

AG Serrano, J Pérez-Gil - Chemistry and physics of lipids, 2006 - Elsevier
Pulmonary surfactant is a lipid–protein complex, synthesized and secreted by the respiratory
epithelium of lungs to the alveolar spaces, whose main function is to reduce the surface …

The closer we look the more we see? Quantitative microscopic analysis of the pulmonary surfactant system

M Ochs - Cellular Physiology and Biochemistry, 2009 - karger.com
The surfactant system of the lung has essential biophysical and immunomodulatory
functions. Only at the electron microscopic level does surfactant reveal its morphological …

Pulmonary surfactant apoproteins: a review of protein and genomic structure

S Hawgood - American Journal of Physiology-Lung Cellular …, 1989 - journals.physiology.org
In recent years, as the complexity of the surfactant system has become more apparent,
investigators with an increasingly diverse set of skills have been attracted to the study of this …

Pulmonary surfactant metabolism in the alveolar airspace: Biogenesis, extracellular conversions, recycling

B Olmeda, M Martínez-Calle, J Pérez-Gil - Annals of Anatomy …, 2017 - Elsevier
Pulmonary surfactant is a lipid–protein complex that lines and stabilizes the respiratory
interface in the alveoli, allowing for gas exchange during the breathing cycle. At the same …