Reperfusion injury in ST-segment elevation myocardial infarction: the final frontier

G Ndrepepa, R Colleran, A Kastrati - Coronary Artery Disease, 2017 - journals.lww.com
ST-segment elevation myocardial infarction is a major cause of morbidity and mortality
worldwide. Reperfusion injury (RI) following the opening of an occluded coronary artery …

Clinical perspectives on reperfusion injury in acute myocardial infarction

KR Bainey, PW Armstrong - American heart journal, 2014 - Elsevier
Prompt reperfusion therapy in acute myocardial infarction enhances clinical outcome.
However, reperfusion itself may contribute to myocardial cell death. The current review …

[HTML][HTML] Treatment of myocardial ischaemia-reperfusion injury in patients with ST-segment elevation myocardial infarction: promise, disappointment, and hope

J He, NG Bellenger, AJ Ludman, AC Shore… - Reviews in …, 2022 - imrpress.com
Acute myocardial infarction (AMI) is a major cause of morbidity and mortality worldwide.
Timely reperfusion with primary percutaneous coronary intervention (PPCI) remains the gold …

Reperfusion injury as a therapeutic challenge in patients with acute myocardial infarction

A Rodríguez-Sinovas, Y Abdallah, HM Piper… - Heart failure …, 2007 - Springer
Cardiomyocyte death secondary to transient ischemia occurs mainly during the first minutes
of reperfusion, in the form of contraction band necrosis involving sarcolemmal rupture …

Protection against myocardial ischemia-reperfusion injury in clinical practice

D Garcia-Dorado, A Rodríguez-Sinovas… - Revista Española de …, 2014 - Elsevier
Even when reperfusion therapy is applied as early as possible, survival and quality of life
are compromised in a considerable number of patients with ST-segment elevation acute …

Reperfusion injury in humans: a review of clinical trials on reperfusion injury inhibitory strategies

MT Dirksen, GJ Laarman, ML Simoons… - Cardiovascular …, 2007 - academic.oup.com
The principal therapy in patients with myocardial infarction to limit infarct size is myocardial
reperfusion by mechanical or pharmacological intervention. Reperfusion has been …

Myocardial reperfusion injury: looking beyond primary PCI

GM Fröhlich, P Meier, SK White, DM Yellon… - European heart …, 2013 - academic.oup.com
Coronary heart disease (CHD) is the leading cause of death and disability in Europe. For
patients presenting with an acute ST-segment elevation myocardial infarction (STEMI) …

Myocardial protection from ischemia-reperfusion injury post coronary revascularization

A Binder, A Ali, R Chawla, HA Aziz… - Expert review of …, 2015 - Taylor & Francis
Effective primary and secondary prevention and advances in cardiac surgery have
significantly improved the care and outcomes of patients with myocardial ischemia. While …

Progression in attenuating myocardial reperfusion injury: an overview

FJP Bernink, L Timmers, AM Beek, M Diamant… - International journal of …, 2014 - Elsevier
Reperfusion by means of percutaneous coronary intervention or thrombolytic therapy is the
most effective treatment for acute myocardial infarction, markedly reducing mortality and …

Targeting reperfusion injury in patients with ST-segment elevation myocardial infarction: trials and tribulations

DJ Hausenloy, HE Botker, T Engstrom… - European heart …, 2017 - academic.oup.com
Ischaemic heart disease (IHD) remains the leading cause of death and disability in Europe
and worldwide. A major cause of morbidity and mortality in IHD patients is an acute ST …