Cellular iron homeostasis and mitochondrial iron homeostasis are interdependent.
Mitochondria must import iron to form iron–sulfur clusters and heme, and to incorporate …

BACKGROUND: Iron is an essential element for life, as it is a cofactor for enzymes involved
in many metabolic processes, but it can also be harmful, since its excess is thought to …

The mitochondrion is well known for its key role in energy transduction. However, it is less
well appreciated that it is also a focal point of iron metabolism. Iron is needed not only for …

Iron is one of the most important elements for life, but excess iron is toxic. Intracellularly,
mitochondria are the center of iron utilization requiring sufficient amounts to maintain normal …

Iron is a crucial transition metal for virtually all life. Two major destinations of iron within
mammalian cells are the cytosolic iron-storage protein, ferritin, and mitochondria. In …

Pathological overload of iron in the mitochondrial matrix has been observed in numerous
diseases, including sideroblastic anemias, which have many causes, and in genetic …

Introduction: Mitochondria are cellular organelles that perform numerous bioenergetic,
biosynthetic, and regulatory functions and play a central role in iron metabolism …

Mitochondria are an iconic distinguishing feature of eukaryotic cells. Mitochondria
encompass an active organellar network that fuses, divides, and directs a myriad of vital …

The mitochondrion plays vital roles in various aspects of cellular metabolism, ranging from
energy transduction and apoptosis to the synthesis of important molecules such as heme …

Iron is a trace element necessary for cell growth, development, and cellular homeostasis, but
insufficient or excessive level of iron is toxic. Intracellularly, sufficient amounts of iron are …