Inflammation is one of a major feature of Parkinson's disease (PD) which poses a threat to
people's health in the world. It has been reported that antioxidation and anti-inflammation …

Parkinson's disease (PD) is a progressive neurodegenerative disorder with a complex
etiology. Neuroinflammation and oxidative stress are important factors driving the …

Microglia are key immune cells in the brain that maintain homeostasis and defend against
immune threats. Targeting the dysfunctional microglia is one of the most promising …

Objective Neuroprotection is a precise target for the treatment of neurodegenerative
diseases, ischemic stroke, and traumatic brain injury. Pyrimidine and its derivatives have …

The 1, 3, 4-oxadiazole derivatives Ox-6a-f have been synthesized by incorporating
flurbiprofen moiety with the aim to explore the potential of target molecules to decrease the …

Background The study aimed to design, synthesize and evaluate various brominated
derivatives of 7-hydroxy coumarin as a new scaffold against Alzheimer's disease by in vivo …

Abstract Alzheimer's disease (AD), a relentless neurodegenerative disorder, is still waiting
for safer profile drugs, risk factors affecting AD's pathogenesis include aβ accumulation, tau …

Parkinson's disease (PD) is the second most common aging-related neurodegenerative
disease worldwide. Oxidative stress and neuroinflammation are critical events in the …

Many naturally existing antioxidants contain coumarin nucleus as a common
pharmacophore whereas benzoxazole is identified as pharmacophore for anti-inflammatory …

Non-steroidal anti-inflammatory drugs (NSAIDs) are widely prescribed to treat inflammatory-
related diseases, pain and fever. However, the prolong use of traditional NSAIDs leads to …