Simple Summary Currently, rodents and pigs are the primary disease models used in
cardiovascular research. Generally, larger animals that are more closely related to humans …

Since induced pluripotent stem (iPS) cells were first generated in 2006 (Takahashi and
Yamanaka, 2006), human iPS cell culture and differentiation into various cell types have …

The generation of induced pluripotent stem cells (iPSCs) has opened up a new scientific
frontier in medicine. This technology has made it possible to obtain pluripotent stem cells …

Genetic cardiac diseases are major causes of morbidity and mortality. Although animal
models have been created to provide some useful insights into the pathogenesis of genetic …

The invention of the induced pluripotent stem cell (iPSC) technology allows patient-specific,
mature somatic cells to be converted into an unlimited supply of pluripotent stem cells …

Cardiometabolic diseases encompass simple monogenic enzyme deficiencies with well-
established pathogenesis and clinical outcomes to complex polygenic diseases such as the …

In recent decades, cardiovascular diseases have become the greatest health threat to
human beings, and thus it is particularly important to explore the subtle underlying …

The advent of induced pluripotent stem cells (iPSCs) has advanced our understanding of the
molecular mechanisms of human disease, drug discovery, and regenerative medicine. As …

For past several decades, laboratory animal models have been the prevailing paradigm for
studying human diseases. A classic approach is to study the impact of specific genes …

An in vitro heart disease model is a promising model used for identifying the genes
responsible for the disease, evaluating the effects of drugs, and regenerative medicine. We …