Over the past ten years, a variety of imaging techniques have been developed that allow
non-invasive detection of gene expression within the brain of intact mammals, ranging from …

Molecular imaging aims to assess non-invasively disease-specific biological and molecular
processes in animal models and humans in vivo. Apart from precise anatomical localisation …

Molecular-genetic imaging in living organisms has become a new field with the exceptional
growth over the past 5 years. Modern imaging is based on three technologies: nuclear …

Neuroimaging allows researchers and clinicians to noninvasively assess structure and
function of the brain. With the advances of imaging modalities such as magnetic resonance …

Monitoring gene expression is crucial for studying the responses of gene therapy and
clarifying gene function in various environments. Molecular imaging is a powerful tool for …

Non-invasive in-vivo molecular genetic imaging developed over the past decade and
predominantly utilises radiotracer (PET, gamma camera, autoradiography), magnetic …

In this second article, we review the various strategies and applications that make use of
reporter genes for molecular imaging of the brain in living subjects. These approaches are …

With more than 20,000 genes in the human genome now identified and a similar number of
genes in the rat and mouse genome known (Gibbs et al., 2004), elucidating their function …

In this first article, we review the basic principles of using reporter genes for molecular
imaging of the brain in living subjects. This approach is emerging as a valuable tool for …

Noninvasive in vivo molecular imaging has developed over the past decade and involves
nuclear (positron emission tomography [PET], gamma camera), magnetic resonance, and in …