Predominantly antibody deficiencies (PADs) are inborn disorders characterized by immune
dysregulation and increased susceptibility to infections. Response to vaccination, including …

Introduction Primary antibody deficiencies (PAD) are inborn defects of the immune system
that result in increased susceptibility to infections. Despite the reduced response to …

Immunocompromised patients, including those with inborn errors of immunity (IEI), may be at
increased risk for severe or prolonged infections with SARS-CoV-2 (Zhu et al. N Engl J Med …

Since the start of the COVID-19 pandemic, in a short span of 3 years, vaccination against
SARS-CoV-2 has resulted in the end of the pandemic. Patients with inborn errors of …

Methods We evaluated anti-SARS-CoV-2 spike antibody levels in 117 PAD patients post-
immunization over five total SARS-CoV-2 vaccine doses and compared this to data in 192 …

Some studies have found increased coronavirus disease-19 (COVID-19)-related morbidity
and mortality in patients with primary antibody deficiencies. Immunization against COVID-19 …

Background Data on immune responses to SARS-CoV-2 in patients with Primary Antibody
Deficiencies (PAD) are limited to infected patients and to heterogeneous cohorts after …

Background Vaccination prevents severe morbidity and mortality from COVID-19 in the
general population. The immunogenicity and efficacy of SARS-CoV-2 vaccines in patients …

Morbidity and mortality of COVID-19 is increased in patients with inborn errors of immunity
(IEI). Age and comorbidities and also impaired type I interferon immunity were identified as …

Background Patients with predominantly antibody deficiency (PAD) have lower anti–severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike antibody levels after initial 2 …