[HTML][HTML] Extracellular vesicles in musculoskeletal pathologies and regeneration

M Herrmann, S Diederichs, S Melnik… - … in Bioengineering and …, 2021 - frontiersin.org
The incidence of musculoskeletal diseases is steadily increasing with aging of the
population. In the past years, extracellular vesicles (EVs) have gained attention in …

Extracellular vesicles in musculoskeletal regeneration: modulating the therapy of the future

H Abreu, E Canciani, D Raineri, G Cappellano… - Cells, 2021 - mdpi.com
Tissue regeneration is a hot topic in health sciences, particularly because effective therapies
promoting the healing of several cell types are lacking, specifically those of the …

[HTML][HTML] Small extracellular vesicles from mesenchymal stromal cells: the next therapeutic paradigm for musculoskeletal disorders

KYW Teo, R Tan, KL Wong, DHW Hey, JHP Hui… - Cytotherapy, 2023 - Elsevier
Musculoskeletal disorders are one of the biggest contributors to morbidity and place an
enormous burden on the health care system in an aging population. Owing to their …

[HTML][HTML] Mesenchymal stem cell-derived extracellular vesicles: a possible therapeutic strategy for orthopaedic diseases: a narrative review

ZL Zeng, H Xie - Biomaterials Translational, 2022 - ncbi.nlm.nih.gov
Accumulating evidence suggests that the therapeutic role of mesenchymal stem cells
(MSCs) in bone diseases is closely related to paracrine-generated extracellular vesicles …

Extracellular vesicles from mesenchymal stem cells as novel treatments for musculoskeletal diseases

MJ Alcaraz, A Compañ, MI Guillén - Cells, 2019 - mdpi.com
Mesenchymal stem/stromal cells (MSCs) represent a promising therapy for musculoskeletal
diseases. There is compelling evidence indicating that MSC effects are mainly mediated by …

Mesenchymal stem cell-derived extracellular vesicles, osteoimmunology and orthopedic diseases

M Ma, G Cui, Y Liu, Y Tang, X Lu, C Yue, X Zhang - PeerJ, 2023 - peerj.com
Mesenchymal stem cells (MSCs) play an important role in tissue healing and regenerative
medicine due to their self-renewal and multi-directional differentiation properties. MSCs …

Mesenchymal stromal cells-derived extracellular vesicles as potential treatments for osteoarthritis

S Yuan, G Li, J Zhang, X Chen, J Su, F Zhou - Pharmaceutics, 2023 - mdpi.com
Osteoarthritis (OA) is a degenerative disease of the joints characterized by cartilage damage
and severe pain. Despite various pharmacological and surgical interventions, current …

Mesenchymal stem cell-derived extracellular vesicles for osteoarthritis treatment: extracellular matrix protection, chondrocyte and osteocyte physiology, pain and …

TH Nguyen, CM Duong, XH Nguyen, UTT Than - Cells, 2021 - mdpi.com
Osteoarthritis (OA) is a common degenerative disease that can lead to persistent pain and
motion restriction. In the last decade, stem cells, particularly mesenchymal stem cells …

Harnessing Engineered Extracellular Vesicles from Mesenchymal Stem Cells as Therapeutic Scaffolds for Bone‐Related Diseases

T Yu, J Wang, Y Zhou, C Ma, R Bai… - Advanced Functional …, 2024 - Wiley Online Library
Mesenchymal stem cells (MSCs) play a crucial role in maintaining bone homeostasis and
are extensively explored for cell therapy in various bone‐related diseases. In addition to …

Therapeutic potential in rheumatic diseases of extracellular vesicles derived from mesenchymal stromal cells

GM Bertolino, M Maumus, C Jorgensen… - Nature Reviews …, 2023 - nature.com
The incidence of rheumatic diseases such as rheumatoid arthritis and osteoarthritis and
injuries to articular cartilage that lead to osteochondral defects is predicted to rise as a result …