Background Neuroapoptosis is induced by the administration of anesthetic agents to the
young. As alpha2 adrenoceptor signaling plays a trophic role during development and is …

Background. Exposure of infant animals to clinically used anaesthetics is associated with
acute structural brain abnormalities and development functional alterations. The α2 …

Background: Recent evidence has demonstrated the anti‐apoptotic of dexmedetomidine in
different brain injury models. Herein, we investigated whether dexmedetomidine could …

Prolonged exposure to volatile anesthetics, such as isoflurane and sevoflurane, causes
neurodegeneration in the developing animal brains. Recent studies showed that …

Background: Anesthetic agents (eg, isoflurane, propofol) may cause neurodegeneration in
the developing brains and impair animals' learning ability. Dexmedetomidine (DEX), a …

Dexmedetomidine, a highly selective α2-adrenergic agonist, has been reported to attenuate
isoflurane-induced cognitive impairment and neuroapoptosis. However, the underlying …

Background In animal models, neonatal exposure to volatile anesthetics induces
neuroapoptosis, leading to memory deficits in adulthood. However, effects of neonatal …

IMPLICATIONS: In a model of excitotoxic brain injury, with striking similarities to human
perinatal hypoxic brain lesions, dexmedetomidine provides potent neuroprotection. This …

The potential for commonly used anesthetics and sedatives to cause neuroapoptosis and
other neurodegenerative changes in the developing mammalian brain has become evident …

Background Ketamine and dexmedetomidine are increasingly used in combination in
pediatric patients. This study examined the hypothesis that dexmedetomidine attenuated …