A mibefradil metabolite is a potent intracellular blocker of L-type Ca2+ currents in pancreatic β-cells
S Wu, M Zhang, PA Vest, A Bhattacharjee, L Liu… - Journal of Pharmacology …, 2000 - ASPET
It has been shown that mibefradil (Ro 40-5967) exerts a selective inhibitory effect on T-type
Ca2+ currents, although at higher concentrations it can antagonize high voltage-activated …
Ca2+ currents, although at higher concentrations it can antagonize high voltage-activated …
High affinity interaction of mibefradil with voltage‐gated calcium and sodium channels
P Eller, S Berjukov, S Wanner, I Huber… - British journal of …, 2000 - Wiley Online Library
Mibefradil is a novel Ca2+ antagonist which blocks both high‐voltage activated and low
voltage‐activated Ca2+ channels. Although L‐type Ca2+ channel block was demonstrated …
voltage‐activated Ca2+ channels. Although L‐type Ca2+ channel block was demonstrated …
Determinants of voltage-dependent inactivation affect Mibefradil block of calcium channels
C Jiménez, E Bourinet, V Leuranguer, S Richard… - …, 2000 - Elsevier
The voltage gated calcium channel family is a major target for a range of therapeutic drugs.
Mibefradil (Ro 40–5967) belongs to a new chemical class of these molecules which differs …
Mibefradil (Ro 40–5967) belongs to a new chemical class of these molecules which differs …
Actions of Mibefradil, Efonidipine and Nifedipine Block of Recombinant T- and L-Type Ca2+ Channels with Distinct Inhibitory Mechanisms
TS Lee, T Kaku, S Takebayashi, T Uchino, S Miyamoto… - Pharmacology, 2006 - karger.com
We compared detailed efficacy of efonidipine and nifedipine, dihydropyridine analogues,
and mibefradil using recombinant T-and L-type Ca2+ channels expressed separately in …
and mibefradil using recombinant T-and L-type Ca2+ channels expressed separately in …
NNC 55-0396 [(1S, 2S)-2-(2-(N-[(3-benzimidazol-2-yl) propyl]-N-methylamino) ethyl)-6-fluoro-1, 2, 3, 4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate …
L Huang, BM Keyser, TM Tagmose, JB Hansen… - … of Pharmacology and …, 2004 - ASPET
Mibefradil is a Ca2+ channel antagonist that inhibits both T-type and high-voltage-activated
Ca2+ channels. We previously showed that block of high-voltage-activated channels by …
Ca2+ channels. We previously showed that block of high-voltage-activated channels by …
Mibefradil reduces blood glucose concentration in db/db mice
Y Lu, M Long, S Zhou, Z Xu, F Hu, M Li - Clinics, 2014 - SciELO Brasil
OBJECTIVE: Numerous recent studies suggest that abnormal intracellular calcium
concentration ([Ca2+] i) is a common defect in diabetic animal models and patients …
concentration ([Ca2+] i) is a common defect in diabetic animal models and patients …
[PDF][PDF] Voltage-dependent blockade of diverse types of voltage-gated Ca2+ channels expressed in Xenopus oocytes by the Ca2+ channel antagonist mibefradil (Ro …
I Bezprozvanny, RW Tsien - Molecular pharmacology, 1995 - Citeseer
Four different types of Ca2 channel cxl subunits, representing the major classes of voltage-
gated Ca2 channels, were mdividually coexpressed along with cs2Th and f32b subunits in …
gated Ca2 channels, were mdividually coexpressed along with cs2Th and f32b subunits in …
Single-channel pharmacology of mibefradil in human native T-type and recombinant Cav3. 2 calcium channels
G Michels, J Matthes, R Handrock, U Kuchinke… - Molecular …, 2002 - ASPET
To study the molecular pharmacology of low-voltage–activated calcium channels in
biophysical detail, human medullary thyroid carcinoma (hMTC) cells were investigated using …
biophysical detail, human medullary thyroid carcinoma (hMTC) cells were investigated using …
Mibefradil (Ro 40-5967): the first selective T-type Ca2+ channel blocker
SI Ertel, JP Clozel - Expert opinion on investigational drugs, 1997 - Taylor & Francis
Mibefradil is a novel Ca2+ antagonist acting on both L-and T-type Ca2+ channels, with a ten-
fold selectivity for T-type Ca2+ channels. It belongs to a chemical class different from other …
fold selectivity for T-type Ca2+ channels. It belongs to a chemical class different from other …
Inhibition of T-type and L-type calcium channels by mibefradil: physiologic and pharmacologic bases of cardiovascular effects
V Leuranguer, ME Mangoni, J Nargeot… - Journal of …, 2001 - journals.lww.com
Ca 2+ channel antagonists of the dihydropyridine, benzothiazepine, and phenylalkylamine
classes have selective effects on L-type versus T-type Ca 2+ channels. In contrast …
classes have selective effects on L-type versus T-type Ca 2+ channels. In contrast …