Endothelium‐dependent smooth muscle hyperpolarization: do gap junctions provide a unifying hypothesis?

TM Griffith - British journal of pharmacology, 2004 - Wiley Online Library
An endothelium‐derived hyperpolarizing factor (EDHF) that is distinct from nitric oxide (NO)
and prostanoids has been widely hypothesized to hyperpolarize and relax vascular smooth …

The obligatory link: role of gap junctional communication in endothelium-dependent smooth muscle hyperpolarization

TM Griffith, AT Chaytor, DH Edwards - Pharmacological research, 2004 - Elsevier
Although an endothelium-derived hyperpolarizing factor (EDHF) has often been
hypothesized to underpin vascular relaxations that are independent of nitric oxide (NO) and …

Endothelium-derived hyperpolarizing factor: where are we now?

M Félétou, PM Vanhoutte - Arteriosclerosis, thrombosis, and …, 2006 - Am Heart Assoc
The endothelium controls vascular tone not only by releasing nitric oxide (NO) and
prostacyclin but also by other pathways causing hyperpolarization of the underlying smooth …

Endothelium-Derived Hyperpolarizing Factor and Myoendothelial Coupling: The in vivo Perspective

K Schmidt, C De Wit - Frontiers in Physiology, 2020 - frontiersin.org
The endothelium controls vascular tone adopting blood flow to tissue needs. It releases
chemical mediators [eg, nitric oxide (NO), prostaglandins (PG)] and exerts appreciable …

Endothelium-dependent hyperpolarizations: the history

PM Vanhoutte - Pharmacological research, 2004 - Elsevier
Endothelial cells control the tone and the growth of the underlying vascular smooth muscle
by releasing Nitric Oxide (NO). This introduction summarizes the early experiments which …

Hydrogen peroxide as an endothelium-derived hyperpolarizing factor

H Shimokawa, T Matoba - Pharmacological research, 2004 - Elsevier
Vascular endothelium plays an important role in maintaining vascular homeostasis by
synthesizing and releasing several vasodilating factors, such as prostacyclin, nitric oxide …

Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in animals and humans

T Matoba, H Shimokawa - Journal of pharmacological sciences, 2003 - jstage.jst.go.jp
Vascular endothelium plays an important role in maintaining vascular homeostasis by
synthesizing and releasing several vasodilating factors, such as prostacyclin, nitric oxide …

Endothelium‐derived hyperpolarizing factor: Is there a novel chemical mediator?

CR Triggle, H Ding - Clinical and Experimental Pharmacology …, 2002 - Wiley Online Library
Endothelium‐derived hyperpolarization (EDH) has been reported in many vessels and an
extensive literature suggests that a novel, non‐nitric oxide and non‐prostanoid, endothelium …

Contribution of endothelium‐derived hyperpolarizing factors to the regulation of vascular tone in humans

J Bellien, C Thuillez… - Fundamental & clinical …, 2008 - Wiley Online Library
Endothelium plays a crucial role in the regulation of cardiovascular homeostasis through the
release of vasoactive factors. Besides nitric oxide (NO) and prostacyclin, increasing …

Involvement of myoendothelial gap junctions in the actions of endothelium-derived hyperpolarizing factor

SL Sandow, M Tare, HA Coleman, CE Hill… - Circulation …, 2002 - Am Heart Assoc
The nature of the vasodilator endothelium-derived hyperpolarizing factor (EDHF) is
controversial, putatively involving diffusible factors and/or electrotonic spread of …