Excess caloric intake can lead to insulin resistance. The underlying reasons are complex but
likely related to ectopic lipid deposition in nonadipose tissue. We hypothesized that the …

Adiponectin, a physiologically active polypeptide secreted by adipocytes, shows insulin-
sensitizing, anti-inflammatory, and antiatherogenic properties in rodents and humans. To …

To examine the peripheral and central roles of adiponectin in energy intake and
expenditure, we investigated the effects of adiponectin on food intake, adiposity, sympathetic …

Adiposity, particularly increased intra-abdominal fat, is a predisposing factor for the
development of insulin resistance in obesity and type 2 diabetes. Visceral fat seems to differ …

Metabolically healthy individuals effectively adapt to changes in nutritional state. Here, we
focus on the effects of the adipocyte-derived secretory molecule adiponectin on adipose …

It is now recognized that the white adipose tissue (WAT) produces a variety of bioactive
peptides, collectively termed “adipokines”. Alteration of WAT mass in obesity or lipoatrophy …

Objective: This study was designed to test whether adiponectin plays a role in diet‐induced
obesity and insulin resistance and acts as a mediator to induce or inhibit specific metabolic …

Objective: Adverse effects of obesity on glucose homeostasis are linked to low-grade
adipose tissue inflammation and accumulation of lipids in non-adipose tissues. The goal of …

Severe adipose tissue deficiency (lipoatrophy) causes insulin-resistant diabetes, elevated
serum triglyceride and fatty acid levels, and massive triglyceride deposition in the liver. In …

Context: In the ob/ob mice, keeping adiponectin concentrations in the physiological range
(through overexpression of this gene in the adipose tissue) results in expansion of fat mass …