As hematopoietic cells proceed in differentiation from stem cells to committed progenitors to
later stage mature forms, they undergo a sequence of morphologic, immunophenotypic, and …

This review gives an account of the clinical and hematologic features of the myelodysplastic
syndromes. It supplies the latest classification of these disorders, discusses the cytogenetic …

At the beginning of the 20th century, the increasingly common use of blood cell counts and
examination of the stained blood film resulted in reports in the medical literature of highly …

The myelodysplastic syndromes (MDS) constitute a heterogeneous group of clonal
disorders arising from a multipotent haemopoietic progenitor which share a leukaemic …

These two issues of the Seminars in Hematology will provide the physician the necessary
knowledge to help make sense of this somewhat confusing array of diseases. The …

Since the initial efforts to characterize the myelodysplastic syndromes in 1976, an extensive
body of information has accumulated defining biologic features and the relation to clinical …

The myelodysplastic syndromes are a heterogeneous group of clonal hematopoietic
disorders predominantly affecting the elderly. Patients frequently develop acute leukemia …

The myelodysplastic syndromes are a heterogeneous group of hematopoietic stem cell
disorders characterized by dysplastic and ineffective hematopoiesis and a varying risk of …

The myelodysplastic syndromes constitute a fascinating model for monoclonal premalignant
disorders. Haemopoiesis is 'dysplastic'with inefficient maturation of a slowly expanding or …

Figure 1. The pathogenesis and evolution of MDS from normal to a leukemic hematopoiesis,
Patients with MDS may die from their cytopenia at the preleukemic stage prior to leukemic …