Regeneration is bungled following CNS injuries, including spinal cord injury (SCI). Inherent
decay of permissive conditions restricts the regrowth of the mature CNS after an injury …

The Rho signaling pathway regulates the cytoskeleton and motility and plays an important
role in neuronal growth inhibition. Here we demonstrate that inactivation of Rho or its …

Rho kinase (ROCK) is a serine/threonine kinase and a downstream target of the small
GTPase Rho. The RhoA/ROCK pathway is associated with various neuronal functions such …

Several major advances in our understanding of axon regeneration and functional repair in
the central nervous system (CNS) together with new insights about molecular signaling …

Paralysis following spinal cord injury (SCI) is due to failure of axonal regeneration. It is
believed that the capacities of neurons to regrow their axons are due partly to their intrinsic …

Rho is an important signaling target to promote repair following spinal cord injury (SCI).
Myelinderived inhibitory proteins, as well as other classes of known growth inhibitory …

An inhibitory extracellular milieu and neuron-intrinsic processes prevent axons from
regenerating in the adult central nervous system (CNS). Here we show how the two aspects …

After a spinal cord injury (SCI), CNS axons fail to regenerate, resulting in permanent deficits.
This is due to:(1) the presence of inhibitory molecules, eg, chondroitin sulfate proteoglycans …

Background The Rho pathway has been shown to have a role in the pathophysiology of
spinal cord injury (SCI). Upregulation of the Rho signaling pathway occurs as a result of SCI …

Rho-kinase (ROCK) is a serine/threonine kinase and one of the major downstream effectors
of the small GTPase Rho. The Rho-ROCK pathway is involved in many aspects of neuronal …