Understanding the dynamics of stem cell lineages is of central importance both for healthy
and cancerous tissues. We study stochastic population dynamics of stem cells and …

Tissue development and homeostasis are thought to be regulated endogenously by control
loops that ensure that the numbers of stem cells and daughter cells are maintained at …

In self-renewing tissues, cell lineages consisting of stem cell and classes of daughter cells
are the basic units which are responsible for the correct functioning of the organ. Cell …

The ability of a few stem-cells to repopulate a severely damaged bone marrow (BM)
guarantees the stability of our physical existence, and facilitates successful BM …

Stem cells are fundamental to human life and offer great therapeutic potential, yet their
biology remains incompletely—or in cases even poorly—understood. The field of stem cell …

Multicellular tissues are continually turning over, and homeostasis is maintained through
regulated proliferation and differentiation of stem cells and progenitors. Following tissue …

In this chapter we present an overview of different mathematical and numerical approaches
to describe stem cell proliferation and differentiation and the development of small cancer …

Stem cells dynamics is an important field of research with promising clinical impacts. Due to
the revolutionary new technologies of biological data collection, an enormous amount of …

Recent discovery of cancer stem cells in tumorigenic tissues has raised many questions
about their nature, origin, function and their behavior in cell culture. Most of current …

The exact mechanisms of spontaneous tumor remission or complete response to treatment
are phenomena in oncology that are not completely understood. We use a concept from …