[HTML][HTML] Epigallocatechin-3-gallate and trichostatin A synergistically inhibit human lymphoma cell proliferation through epigenetic modification of p16INK4a
DS Wu, JZ Shen, AF Yu, HY Fu… - Oncology …, 2013 - spandidos-publications.com
DNA methylation and histone deacetylation play important roles in the occurrence and
development of cancers by inactivating the expression of tumor suppressors, including …
development of cancers by inactivating the expression of tumor suppressors, including …
(−)-Epigallocatechin-3-gallate reactivates silenced tumor suppressor genes, Cip1/p21 and p 16 INK4a , by reducing …
V Nandakumar, M Vaid, SK Katiyar - Carcinogenesis, 2011 - academic.oup.com
The anti-skin carcinogenic effects of green tea catechins have been studied extensively in
vitro and in vivo models but the precise epigenetic molecular mechanisms are still unclear …
vitro and in vivo models but the precise epigenetic molecular mechanisms are still unclear …
[HTML][HTML] Promoter and histone methylation and p16INK4A gene expression in colon cancer
The inactivation of the cyclin-dependent kinase inhibitor p16INK4A gene by
hypermethylation is observed in numerous types of cancer. New findings indicate that DNA …
hypermethylation is observed in numerous types of cancer. New findings indicate that DNA …
Azacitidine induces demethylation of p16INK4a and inhibits growth in adult T-cell leukemia/lymphoma
K Uenogawa, Y Hatta, N Arima… - International …, 2011 - spandidos-publications.com
Adult T-cell leukemia/lymphoma (ATL) is one of the peripheral T-cell malignant neoplasms
strongly associated with human T-cell leukemia virus type-I (HTLV-I). Although the viral …
strongly associated with human T-cell leukemia virus type-I (HTLV-I). Although the viral …
5-Aza-2′-deoxycytidine leads to down-regulation of aberrant p16INK4A RNA transcripts and restores the functional retinoblastoma protein pathway in hepatocellular …
SI Suh, HY Pyun, JW Cho, WK Baek, JB Park… - Cancer letters, 2000 - Elsevier
The inactivation of the cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor p16INK4A may
be caused by gene deletion, mutation or promoter hypermethylation. We have previously …
be caused by gene deletion, mutation or promoter hypermethylation. We have previously …
[HTML][HTML] Epigallocatechin-3-gallate inhibits growth and induces apoptosis in esophageal cancer cells through the demethylation and reactivation of the p16 gene
J Meng, Q Tong, X Liu, Z Yu, J Zhang… - Oncology …, 2017 - spandidos-publications.com
The present study aimed to investigate the effect of treatment with epigallocatechin-3-gallate
(EGCG) on the human esophageal cancer cell line ECa109 and elucidate the associated …
(EGCG) on the human esophageal cancer cell line ECa109 and elucidate the associated …
[HTML][HTML] A genome-wide study of DNA methylation modified by epigallocatechin-3-gallate in the CAL-27 cell line
LL Chen, WF Han, Y Geng… - Molecular Medicine …, 2015 - spandidos-publications.com
In order to gain greater understanding of the mechanisms underlying the effect of
epigallocatechin-3-gallate (EGCG) on DNA methylation and its chemopreventative action in …
epigallocatechin-3-gallate (EGCG) on DNA methylation and its chemopreventative action in …
Silencing of the p18INK4c gene by promoter hypermethylation in Reed-Sternberg cells in Hodgkin lymphomas
A Sánchez-Aguilera, J Delgado, FI Camacho… - Blood, 2004 - ashpublications.org
Abstract p18INK4c is a cyclin-dependent kinase (CDK) inhibitor that interferes with the Rb-
kinase activity of CDK6/CDK4. Disruption of p18INK4c in mice impairs B-cell terminal …
kinase activity of CDK6/CDK4. Disruption of p18INK4c in mice impairs B-cell terminal …
[HTML][HTML] Epigallocatechin Gallate (EGCG), an active phenolic compound of Green Tea, inhibits Tumor Growth of Head and Neck Cancer cells by targeting DNA …
Head and neck cancers are among the deadliest cancers, ranked sixth globally in rates of
high mortality and poor patient prognoses. The prevalence of head and neck squamous cell …
high mortality and poor patient prognoses. The prevalence of head and neck squamous cell …
Decitabine induces cell cycle arrest at the G1 phase via p21WAF1 and the G2/M phase via the p38 MAP kinase pathway
D Lavelle, J DeSimone, M Hankewych… - Leukemia research, 2003 - Elsevier
Methylation of the p16 INK4a tumor suppressor gene is observed frequently in multiple
myeloma and various forms of lymphoma and mediates silencing of p16 gene expression. In …
myeloma and various forms of lymphoma and mediates silencing of p16 gene expression. In …