Early exposure to dibutyl phthalate (DBP) can cause hypospadias in newborn foetuses.
However, the underlying molecular mechanism is not well defined. Aberrant angiogenesis is …

Di-n-butyl phthalate (DBP) is a plasticizer commonly used in industrial production and is
present in our daily life. It has been confirmed that DBP causes genitourinary malformations …

Objective This study focused on the oxidative stress effect of di-n-butyl phthalate (DBP) on
development of the urinary system. Methods We examined the mRNA expression of genital …

Maternal exposure to di-n-butyl phthalate (DBP) induces hypospadias, but the underlying
mechanisms remain elusive. Here we hypothesize that aberrant activation of autophagy and …

Phthalates are known to elicit marked effects on the developing male reproductive tract as
evidenced by hypospadias. Recently, transforming growth factor-β1 (TGF-β1) was …

Anorectal malformations in combination with hypospadias (ARMs & hypospadias) are a type
of complex congenital malformations. The underlying mechanisms of this deformity are …

The objective of this study was to first evaluate the developmental abnormalities and carry
out the molecular analysis of external genitalia in newborn hypospadiac male rats induced …

Dibutyl phthalate (DBP) is an endocrine disruptor that has been widely used in various
products of human use. DBP exposure has been associated with reproductive and …

Maternal exposure to di-n-butyl phthalate (DBP) induces hypospadias via regulation of
autophagy in uroepithelial cells. Here, we use gene express analysis to explore the …

Fibroblast growth factor 8 (FGF8) is an androgen-induced growth factor (AIGF) that is crucial
for embryonic development. This study was developed to investigate the role of FGF8 in …