Stem cells have the unique capacity to differentiate into many cell types during embryonic
development and postnatal growth. Through coordinated cellular behaviors (self‐renewal …

The maintenance of cellular identity requires continuous adaptation to environmental
changes. This process is particularly critical for stem cells, which need to preserve their …

Highlights•Mitochondrial-mediated signaling regulates the fate of stem cells.•Activation of
mitochondrial OXPHOS is an upstream mechanism in the differentiation …

Mesenchymal stem cells (MSCs) are pivotal to tissue homeostasis, repair, and regeneration
due to their potential for self-renewal, multilineage differentiation, and immune modulation …

Mitochondria are considered highly plastic organelles. This plasticity enables the
mitochondria to undergo morphological and functional changes in response to cellular …

Regulated mechanisms of stem cell maintenance are key to preventing stem cell depletion
and aging. While mitochondrial morphology plays a fundamental role in tissue development …

The importance of mitochondria in energy metabolism, signal transduction and aging in post-
mitotic tissues has been well established. Recently, the crucial role of mitochondrial-linked …

As sites of cellular respiration and energy production, mitochondria play a central role in cell
metabolism. Cell differentiation is associated with an increase in mitochondrial content and …

Recent evidence supports the notion that mitochondrial metabolism is necessary for the
determination of stem cell fate. Historically, mitochondrial metabolism is linked to the …

Mitochondria are highly dynamic organelles that continuously change their shape. Their
main function is adenosine triphosphate (ATP) production; however, they are additionally …