Integration of lipidomics and metabolomics for in-depth understanding of cellular mechanism and disease progression

R Wang, B Li, SM Lam, G Shui - Journal of genetics and genomics, 2020 - Elsevier
Mass spectrometry (MS)-based omics technologies are now widely used to profile small
molecules in multiple matrices to confer comprehensive snapshots of cellular metabolic …

Metabolomics: basic principles and strategies

S Nalbantoglu - Molecular medicine, 2019 - books.google.com
Metabolomics is the study of metabolome within cells, biofluids, tissues, or organisms to
comprehensively identify and quantify all endogenous and exogenous low-molecular …

Lipidomics at the interface of structure and function in systems biology

RW Gross, X Han - Chemistry & biology, 2011 - cell.com
Cells, tissues, and biological fluids contain a diverse repertoire of many tens of thousands of
structurally distinct lipids that play multiple roles in cellular signaling, bioenergetics, and …

Lipidomics as a principal tool for advancing biomedical research

SM Lam, G Shui - Journal of Genetics and Genomics, 2013 - Elsevier
Lipidomics, which targets at the construction of a comprehensive map of lipidome
comprising the entire lipid pool within a cell or tissue, is currently emerging as an …

Lipidomics applications for disease biomarker discovery in mammal models

YY Zhao, XL Cheng, RC Lin, F Wei - Biomarkers in medicine, 2015 - Taylor & Francis
Lipidomics is a lipid-targeted metabolomics approach focusing on comprehensive analysis
of all lipids with which they interact in biology systems. Recent technological advances in …

Lipidomics: Novel insight into the biochemical mechanism of lipid metabolism and dysregulation-associated disease

YY Zhao, H Miao, XL Cheng, F Wei - Chemico-Biological Interactions, 2015 - Elsevier
The application of lipidomics, after genomics, proteomics and metabolomics, offered largely
opportunities to illuminate the entire spectrum of lipidome based on a quantitative or semi …

Metabolomics: beyond biomarkers and towards mechanisms

CH Johnson, J Ivanisevic, G Siuzdak - Nature reviews Molecular cell …, 2016 - nature.com
Metabolomics, which is the profiling of metabolites in biofluids, cells and tissues, is routinely
applied as a tool for biomarker discovery. Owing to innovative developments in informatics …

High-coverage lipidomics for functional lipid and pathway analyses

SM Lam, Z Wang, B Li, G Shui - Analytica Chimica Acta, 2021 - Elsevier
Rapid advances in front-end separation approaches and analytical technologies have
accelerated the development of lipidomics, particularly in terms of increasing analytical …

Lipidomics for studying metabolism

X Han - Nature Reviews Endocrinology, 2016 - nature.com
Many thousands of lipid species exist and their metabolism is interwoven via numerous
pathways and networks. These networks can also change in response to cellular …

Exploring disease through metabolomics

N Vinayavekhin, EA Homan… - ACS chemical biology, 2010 - ACS Publications
Metabolomics approaches provide an analysis of changing metabolite levels in biological
samples. In the past decade, technical advances have spurred the application of …