Androgen deprivation therapy or ADT is one of the cornerstones of management of locally
advanced or metastatic prostate cancer, alongside radiation therapy. However, despite early …

Prostate cancer is the second-leading cause of cancer-related mortality in men in Western
societies. Androgen receptor (AR) signaling is a critical survival pathway for prostate cancer …

Androgen receptor (AR) signaling is a critical pathway for prostate cancer cells, and
androgen-deprivation therapy (ADT) remains the principal treatment for patients with locally …

The role of the androgen receptor (AR) signaling axis in the progression of prostate cancer
is a cornerstone to our understanding of the molecular mechanisms causing castration …

Prostate cancer has become a real public health issue in industrialized countries, mainly
due to patients' relapse by castration-refractory disease after androgen ablation. Castration …

Simple Summary Castration-resistant prostate cancer (CRPC) remains a significant medical
challenge, even with recent advancements in diagnosis and treatment. To improve patient …

What's known on the subject? and What does the study add? Castration resistance has
been appreciated for decades, and several mechanisms theorising on this effect have been …

With increases in the mortality rate and number of patients with prostate cancer (PCa), PCa,
particularly the advanced and metastatic disease, has been the focus of a number of studies …

Androgen deprivation therapy has been the major treatment for advanced prostate cancer
(PCa) and has shown to prolong life. However, remissions are temporary and patients …

Simple Summary Prostate cancer can develop under hormone treatment and chemotherapy
from a castration-sensitive towards a castration-resistant into a drug resistant-tumor. The …