Neuroprotection seeks to restrict injury to the brain parenchyma following an ischaemic
insult by preventing salvageable neurons from dying. The concept of neuroprotection has …

Stroke is the third cause of death worldwide and the main cause of chronic, severe adult
disability. We focus on acute ischaemic stroke, which accounts for approximately 80% of all …

Background Neuroprotection for ischemic stroke is a growing field, built upon the elucidation
of the biochemical pathways of ischemia first studied in the 1970s. Beginning in the early …

Stroke is a devastating medical condition, killing millions of people each year and causing
serious injury to many more. Despite advances in treatment, there is still little that can be …

Abstract 'Neuroprotection'is a term used to describe the putative effect of interventions
protecting the brain from pathological damage. In occlusive stroke, the concept of …

Neuroprotection for ischemic stroke refers to strategies, applied singly or in combination, that
antagonize the injurious biochemical and molecular events that eventuate in irreversible …

Neuroprotection remains one of the holy grails of acute ischemic stroke therapy. The ability
to protect the ischemic brain from injury until reperfusion and then to protect the brain from …

The concept of neuroprotection relies on the principle that delayed neuronal injury occurs
after ischemia. The phenomenon of the “ischemic cascade” has been described, and each …

Abundant preclinical studies have identified multiple mechanisms of ischemic brain injury
and have provided proof of principle that strategies designed to counter these mechanisms …

Investigators acknowledge the limitations of rodent or non-human primate stroke models,
hundreds of putative neuroprotectants have been evaluated in preclinical models, but not …