D-Glucose directly generates 2-keto-L-gulonic acid (2-KLG, precursor of vitamin C) through
the 2, 5-diketo-D-gluconic acid (2, 5-DKG) pathway. 2, 5-DKG is the main rate-limiting factor …

Direct production of 2-keto-L-gulonic acid (2-KLG, the precursor of vitamin C) from D-
glucose through 2, 5-diketo-D-gluconic acid (2, 5-DKG) is a promising alternative route. To …

keto-d-gluconic acid (2-KGA) is a key precursor for synthesising vitamin C and isovitamin C.
However, phage contamination is as constant problem in industrial production of 2-KGA …

The direct fermentation of the precursor of vitamin C, 2-keto-L-gulonic acid (2-KLG), has
been a long-pursued goal. Previously, a strain of Gluconobacter oxydans WSH-004 was …

Diketo-d-gluconate (2, 5DKG) is a compound that can be the intermediate for d-tartrate and
also vitamin C production. Although Gluconobacter oxydans NBRC3293 produces 2, 5DKG …

Abstract Background L-(+)-tartaric acid (L-TA) is an important organic acid, which is
produced from the cream of tartar or stereospecific hydrolysis of the cis-epoxysuccinate. The …

keto-D-gluconic acid is an important precursor for D-isoascorbic acid and sodium D-
isoascorbate, a significant antioxidant and food additive. Gluconobacter suboxydans has …

Abstract Background 2-keto-d-gluconic acid (2KGA) is widely used as a chemical
intermediate in the cosmetic, pharmaceutical and environmental industries. Several …

Keto-l-gulonic acid (2-KLG), the direct precursor of vitamin C, is currently produced by a two-
step fermentation route from d-sorbitol. However, this route involves three bacteria, making …

The rapid and incomplete oxidation of sugars, alcohols, and polyols by the gram-negative
bacterium Gluconobacter oxydans facilitates a wide variety of biological applications. For the …