Selective progesterone receptor modulators—mechanisms and therapeutic utility
Selective progesterone receptor modulators (SPRMs) are a new class of compounds
developed to target the progesterone receptor (PR) with a mix of agonist and antagonist …
developed to target the progesterone receptor (PR) with a mix of agonist and antagonist …
[HTML][HTML] Selective progesterone receptor modulators in reproductive medicine: pharmacology, clinical efficacy and safety
P Bouchard, N Chabbert-Buffet, BCJM Fauser - Fertility and sterility, 2011 - Elsevier
OBJECTIVE: To discuss the mechanism of action of selective progesterone receptor
modulators (SPRMs) and summarize the preclinical and clinical efficacy and safety data …
modulators (SPRMs) and summarize the preclinical and clinical efficacy and safety data …
Selective progesterone receptor modulator development and use in the treatment of leiomyomata and endometriosis
K Chwalisz, MC Perez, D DeManno, C Winkel… - Endocrine …, 2005 - academic.oup.com
Selective progesterone receptor modulators (SPRMs) represent a new class of
progesterone receptor ligands. SPRMs exert clinically relevant tissue-selective …
progesterone receptor ligands. SPRMs exert clinically relevant tissue-selective …
Selective progesterone receptor modulators and progesterone antagonists: mechanisms of action and clinical applications
N Chabbert-Buffet, G Meduri… - Human reproduction …, 2005 - academic.oup.com
Since the discovery of the antiprogestin mifepristone, hundreds of similar compounds have
been synthesized, which can be grouped in a large family of progesterone receptor ligands …
been synthesized, which can be grouped in a large family of progesterone receptor ligands …
Progesterone receptor modulators and progesterone antagonists in women's health
IM Spitz, K Chwalisz - Steroids, 2000 - Elsevier
Both progesterone receptor modulators (PRMs) as well as pure progesterone antagonists
(PAs) have numerous proven and potential therapeutic applications in female health care …
(PAs) have numerous proven and potential therapeutic applications in female health care …
The immninent dawn of SPRMs in obstetrics and gynecology
N Chabbert-Buffet, A Pintiaux, P Bouchard - Molecular and cellular …, 2012 - Elsevier
Selective progesterone receptor modulators (SPRMs) have been developed since the late
70s when mifepristone was first described. They act through nuclear progesterone receptors …
70s when mifepristone was first described. They act through nuclear progesterone receptors …
Selective progesterone receptor modulators (SPRMs): progesterone receptor action, mode of action on the endometrium and treatment options in gynecological …
A Wagenfeld, PTK Saunders, L Whitaker… - Expert opinion on …, 2016 - Taylor & Francis
Introduction: The progesterone receptor plays an essential role in uterine physiology and
reproduction. Selective progesterone receptor modulators (SPRMs) have emerged as a …
reproduction. Selective progesterone receptor modulators (SPRMs) have emerged as a …
Progesterone antagonists and progesterone receptor modulators: an overview
IM Spitz - Steroids, 2003 - Elsevier
Since the original description of the structure of the antiprogestin, mifepristone, was
published, numerous related compounds have been synthesized which may function as …
published, numerous related compounds have been synthesized which may function as …
Therapeutic potential for the selective progesterone receptor modulator asoprisnil in the treatment of leiomyomata
K Chwalisz, D DeManno, R Garg… - Seminars in …, 2004 - thieme-connect.com
Asoprisnil is a novel selective progesterone receptor modulator that exhibits partial agonist
and antagonist activities in animals and humans. It demonstrates a high degree of …
and antagonist activities in animals and humans. It demonstrates a high degree of …
Treatment of endometriosis with the novel selective progesterone receptor modulator (SPRM) asoprisnil
KCC Mattia-Goldberg, M Lee, W Elger… - Fertility and …, 2004 - fertstert.org
Objective Asoprisnil (J867) is a novel SPRM, which shows mixed progesterone
agonist/antagonist activity and endometrial selectivity in animal and humans. In non-human …
agonist/antagonist activity and endometrial selectivity in animal and humans. In non-human …