Selective progesterone receptor modulators (SPRMs) are a new class of compounds
developed to target the progesterone receptor (PR) with a mix of agonist and antagonist …

OBJECTIVE: To discuss the mechanism of action of selective progesterone receptor
modulators (SPRMs) and summarize the preclinical and clinical efficacy and safety data …

Selective progesterone receptor modulators (SPRMs) represent a new class of
progesterone receptor ligands. SPRMs exert clinically relevant tissue-selective …

Since the discovery of the antiprogestin mifepristone, hundreds of similar compounds have
been synthesized, which can be grouped in a large family of progesterone receptor ligands …

Both progesterone receptor modulators (PRMs) as well as pure progesterone antagonists
(PAs) have numerous proven and potential therapeutic applications in female health care …

Selective progesterone receptor modulators (SPRMs) have been developed since the late
70s when mifepristone was first described. They act through nuclear progesterone receptors …

Introduction: The progesterone receptor plays an essential role in uterine physiology and
reproduction. Selective progesterone receptor modulators (SPRMs) have emerged as a …

Since the original description of the structure of the antiprogestin, mifepristone, was
published, numerous related compounds have been synthesized which may function as …

Asoprisnil is a novel selective progesterone receptor modulator that exhibits partial agonist
and antagonist activities in animals and humans. It demonstrates a high degree of …

Objective Asoprisnil (J867) is a novel SPRM, which shows mixed progesterone
agonist/antagonist activity and endometrial selectivity in animal and humans. In non-human …