AIM Colorectal cancer has been described in association with hyperplastic polyposis but the
mechanism underlying this observation is unknown. The aim of this study was to …

BACKGROUND AND AIM Hereditary non-polyposis colorectal cancer (HNPCC), as its name
implies, is associated with few adenomas, and the early evolution of colorectal neoplasia is …

High-level microsatellite instability (MSI-H) is demonstrated in 10 to 15% of sporadic
colorectal cancers and in most cancers presenting in the inherited condition hereditary …

BACKGROUND Little is known about the genetic alterations in multiple primary cancers of
the gastrointestinal tract. Microsatellite instability (MSI) is frequently observed in hereditary …

AIM: To investigate the distribution of DNA microsatellite instability (MSI) in a series of
hyperplastic polyps, serrated adenomas, and mixed polyps of the colorectum. METHODS …

Background & Aims: Genetic instability related to defective DNA mismatch repair genes may
be involved in the pathogenesis of carcinoma in hereditary nonpolyposis colon cancer …

Background: Microsatellite instability (MSI) is seen in 10%–15% of sporadic colorectal
cancers mostly in the right colon, but the precursors of cancers with MSI remain unknown …

Recent studies have demonstrated the presence of microsatellite instability (MSI) in tumors
from patients with hereditary nonpolyposis colorectal cancer and in a large number of …

Microsatellite instability (MSI) is a hallmark of hereditary nonpolyposis colorectal cancer, and
in these patients, results from inherited defects in DNA mismatch repair genes, mostly MSH2 …

BACKGROUND AND AIMS In this study, we prospectively examined the clinical significance
of the microsatellite instability (MSI) phenotype in sporadic colorectal cancer, and …