Mitochondrial dysfunction is a key feature of cancer and is frequently associated with
increased aggressiveness and metastatic potential. Recent evidence has brought to light a …

Breast cancers are very heterogeneous tissues with several cell types and metabolic
pathways together sustaining the initiation and progression of disease and contributing to …

Metabolic synergy or metabolic coupling between glycolytic stromal cells (Warburg effect)
and oxidative cancer cells occurs in human breast cancers and promotes tumor growth. The …

Epithelial-to-mesenchymal transition (EMT) allows epithelial cancer cells to assume
mesenchymal features, endowing them with enhanced motility and invasiveness, thus …

Altered metabolism is a distinct feature of cancer cells. During transformation, the entire
metabolic network is rewired to efficiently convert nutrients to biosynthetic precursors to …

Aerobic glycolysis, also referred to as the Warburg effect, has been regarded as the
dominant metabolic phenotype in cancer cells for a long time. More recently, it has been …

Breast cancer cells can survive and proliferate under harsh conditions of nutrient
deprivation, including limited oxygen and glucose availability. We hypothesized that such …

Here, we used quantitative proteomics analysis to identify novel therapeutic targets in
cancer stem cells and/or progenitor cells. For this purpose, mammospheres from two ER …

This review explores the molecular mechanisms that may be responsible for mitochondrial
retrograde signalling related metabolic reprogramming in cancer and host cells in the …

Simple Summary Metabolic heterogeneity and mitochondrial function are important
parameters that might influence therapeutic vulnerabilities and predict the clinical outcomes …