T cells are primary targets in numerous gene therapy protocols. However, the use of
subgroup C adenovirus serotype 2 or 5 (Ad2 or Ad5) as a vector to transduce T cells is …

Vectors based on human adenovirus serotypes 2 (Ad2) and 5 (Ad5) of species C possess a
number of features that have favored their widespread employment for gene delivery both …

Clinical success in T cell therapy has stimulated widespread efforts to increase safety and
potency and to extend this technology to solid tumors. Yet progress in cell therapy remains …

Efficient infection with adenovirus (Ad) vectors based on serotype 5 (Ad5) requires the
presence of coxsackievirus-adenovirus receptors (CAR) and αv integrins on cells. The …

We developed a new type of adenovirus type 5 (Ad5)-derived vector with genetically
modified fiber proteins whose knob domains could be stripped off due to the insertion of a …

Replication-deficient human adenovirus type 5 (Ad5) can be produced to high titers in
complementing cell lines, such as PER. C6, and is widely used as a vaccine and gene …

Most human carcinoma cell lines lack the high-affinity receptors for adenovirus serotype 5
(Ad5) at their surface and are nonpermissive to Ad5. We therefore tested the efficiency of …

Recombinant, replication-deficient adenoviruses are efficient vectors for gene transfer to a
wide range of cell types, with the exception of T lymphocytes. Here, we show that primary T …

The efficiency of dendritic cells (DC) as immunotherapeutic vaccines critically depends on
optimal delivery of target Ags. Although DC modified by subgroup C type 5 recombinant …

Adenovirus vectors based on human serotype 5 (Ad5) have successfully been used as gene
transfer vectors in many gene therapy-based approaches to treat disease. Despite their …