Our capacity to measure diverse aspects of human biology has developed rapidly in the past
decades, but the rate at which these techniques have generated insights into the biological …

Phenomics is an emerging transdiscipline dedicated to the systematic study of phenotypes
on a genome-wide scale. New methods for high-throughput genotyping have changed the …

There is increasing appreciation that certain biological processes may not be equally related
to all psychiatric symptoms in a given diagnostic category. Research on the biological …

Precision psychiatry demands the rapid, efficient, and temporally dense collection of large
scale and multi-omic data across diverse samples, for better diagnosis and treatment of …

Patients with mental disorders show many biological abnormalities which distinguish them
from normal volunteers; however, few of these have led to tests with clinical utility. Several …

Most neuropsychiatric disorders are highly polygenic, implicating hundreds to thousands of
causal genetic variants that span much of the genome. This widespread polygenicity …

Neurogenetics research has begun to advance our understanding of how genetic variation
gives rise to individual differences in brain function, which, in turn, shapes behavior and risk …

Genetic investigations of psychiatric disease have historically relied on subjectively
assessed disease diagnoses to define phenotypes. Recent developments in several areas …

In this chapter, we have reviewed the behavior genetic literature for a number of the major
forms of child and adult psychopathology, including schizophrenia, schizophrenia spectrum …

Over the last decade, genome-wide association studies of psychiatric disorders have
identified numerous significant loci. Whereas these studies initially depended on cohorts …